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Submit ReviewPotent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable.
M. Wt | 671.52 |
Formula | C33H23F10NO3 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 939390-99-5 |
PubChem ID | 23582473 |
InChI Key | UBJMOTPQBCKENW-WJOKGBTCSA-N |
Smiles | FC1=CC(OC(F)(F)C(F)F)=CC([C@@](NC(C2=CC=C(F)C(C(F)(F)F)=C2)=O)(CC3=CC=CC=C3)C4=CC=C(F)C(OC5CC5)=C4)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 67.15 | 100 | |
ethanol | 67.15 | 100 |
The following data is based on the product molecular weight 671.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.49 mL | 7.45 mL | 14.89 mL |
5 mM | 0.3 mL | 1.49 mL | 2.98 mL |
10 mM | 0.15 mL | 0.74 mL | 1.49 mL |
50 mM | 0.03 mL | 0.15 mL | 0.3 mL |
References are publications that support the biological activity of the product.
Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID: 26524347
If you know of a relevant reference for BMS 795311, please let us know.
Keywords: BMS 795311, BMS 795311 supplier, BMS795311, cholesteryl, ester, transfer, protein, CETP, potent, inhibitors, inhibits, orally, bioavailable, high, density, lipoprotein, cholesterol, HDL-C, Other, Transferases, Lipid, Metabolism, 5762, Tocris Bioscience
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