BMS 795311
Biological Activity
Potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable.
Technical Data
| M. Wt | 671.52 |
| Formula | C33H23F10NO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 939390-99-5 |
| PubChem ID | 23582473 |
| InChI Key | UBJMOTPQBCKENW-WJOKGBTCSA-N |
| Smiles | FC1=CC(OC(F)(F)C(F)F)=CC([C@@](NC(C2=CC=C(F)C(C(F)(F)F)=C2)=O)(CC3=CC=CC=C3)C4=CC=C(F)C(OC5CC5)=C4)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 67.15 | 100 | |
| ethanol | 67.15 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 671.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.49 mL | 7.45 mL | 14.89 mL |
| 5 mM | 0.3 mL | 1.49 mL | 2.98 mL |
| 10 mM | 0.15 mL | 0.74 mL | 1.49 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.3 mL |
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References
References are publications that support the products' biological activity.
Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID: 6524347
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Keywords: BMS795311 cholesteryl ester transfer protein CETP potent inhibitors inhibits orally bioavailable high density lipoprotein cholesterol HDL-C Other Transferases
Citations for BMS 795311
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Literature in this Area
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