BMS 795311

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Cat.No. 5762 - BMS 795311 | C33H23F10NO3 | CAS No. 939390-99-5
Description: Potent cholesteryl ester transfer protein (CETP) inhibitor
Chemical Name: N-[(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)

Biological Activity for BMS 795311

BMS 795311 is a potent cholesteryl ester transfer protein (CETP) inhibitor (IC50 = 4 nM in an enzyme-based scintillation proximity assay). Inhibits cholesteryl ester transfer and increases HDL-C levels in vivo. Orally bioavailable.

Technical Data for BMS 795311

M. Wt 671.52
Formula C33H23F10NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 939390-99-5
PubChem ID 23582473
Smiles FC1=CC(OC(F)(F)C(F)F)=CC([C@@](NC(C2=CC=C(F)C(C(F)(F)F)=C2)=O)(CC3=CC=CC=C3)C4=CC=C(F)C(OC5CC5)=C4)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 795311

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 67.15 100
ethanol 67.15 100

Preparing Stock Solutions for BMS 795311

The following data is based on the product molecular weight 671.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.49 mL 7.45 mL 14.89 mL
5 mM 0.3 mL 1.49 mL 2.98 mL
10 mM 0.15 mL 0.74 mL 1.49 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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References for BMS 795311

References are publications that support the biological activity of the product.

Qiao et al (2015) Triphenylethanamine derivatives as cholesteryl ester transfer protein inhibitors: discovery of N-[(1R)-1-(3-cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamid J.Med.Chem. 58 9010 PMID: 26524347

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