Highly potent and selective androgen receptor (AR) agonist (EC50 = 0.44 nM). Exhibits selectivity for ARs over estrogen, glucocorticoid and mineralocorticoid receptors and no significant binding to steroid hormone binding globulin or aromatase. Also exhibits selectivity for muscle over prostate ARs. Active in vivo and orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 305.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.27 mL||16.35 mL||32.71 mL|
|5 mM||0.65 mL||3.27 mL||6.54 mL|
|10 mM||0.33 mL||1.64 mL||3.27 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References are publications that support the biological activity of the product.
Ostrowski et al (2007) Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology 148 4
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