BMS 303141

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Cat.No. 4609 - BMS 303141 | C19H15Cl2NO4S | CAS No. 943962-47-8
Description: ATP citrate lyase inhibitor; orally bioavailable
Chemical Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable.

Technical Data

M. Wt 424.3
Formula C19H15Cl2NO4S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 943962-47-8
PubChem ID 90488956
InChI Key LIZVMVYXZWADCK-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(O)C=C1S(NC2=C(C3=CC=CC=C3)C=CC(OC)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.24 10
ethanol 21.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 424.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.78 mL 23.57 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Li et al (2007) 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg.Med.Chem.Lett. 17 3208 PMID: 17383874

Ma et al (2009) A novel direct homogeneous assay for ATP citrate lyase. J.Lipid Res. 50 2131 PMID: 19286649


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Keywords: BMS303141 ATP citrate lyases inhibits inhibitors plasma glucose triglycerides orally bioavailable synthases transferases ACLY ATP Citrate Lyase

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