BMS 303141

Pricing Availability   Qty
Description: ATP citrate lyase inhibitor; orally bioavailable
Chemical Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations (9)
Reviews

Biological Activity for BMS 303141

BMS 303141 is an ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia; reduces cell proliferation in HepG2 and Huh-7 cell lines and in PD-1 deficient lymphomas. Orally bioavailable.

Technical Data for BMS 303141

M. Wt 424.3
Formula C19H15Cl2NO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 943962-47-8
PubChem ID 90488956
InChI Key LIZVMVYXZWADCK-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(O)C=C1S(NC2=C(C3=CC=CC=C3)C=CC(OC)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 303141

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.24 10
ethanol 21.21 50

Preparing Stock Solutions for BMS 303141

The following data is based on the product molecular weight 424.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.71 mL 23.57 mL 47.14 mL
2.5 mM 0.94 mL 4.71 mL 9.43 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets for BMS 303141

Certificate of Analysis / Product Datasheet
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References for BMS 303141

References are publications that support the biological activity of the product.

Li et al (2007) 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg.Med.Chem.Lett. 17 3208 PMID: 17383874

Ma et al (2009) A novel direct homogeneous assay for ATP citrate lyase. J.Lipid Res. 50 2131 PMID: 19286649

Wartewig et al (2023) PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat.Cancer 4 1508 PMID: 37723306


If you know of a relevant reference for BMS 303141, please let us know.

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Keywords: BMS 303141, BMS 303141 supplier, BMS303141, ATP, citrate, lyases, inhibits, inhibitors, plasma, glucose, triglycerides, orally, bioavailable, synthases, transferases, ACLY, immunometabolism, Citrate, Lyase, 4609, Tocris Bioscience

9 Citations for BMS 303141

Citations are publications that use Tocris products. Selected citations for BMS 303141 include:

Lars et al (2020) Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. Front Immunol 11 1968 PMID: 32849657

Dong et al (2020) Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation. Nat Commun 11 3806 PMID: 32732922

Wartewig et al (2023) PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat.Cancer 4 1508 PMID: 37723306

Namgaladze et al (2018) Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Front Immunol 9 2858 PMID: 30568658


Do you know of a great paper that uses BMS 303141 from Tocris? Please let us know.

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