BMS 303141

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Cat.No. 4609 - BMS 303141 | C19H15Cl2NO4S | CAS No. 943962-47-8
Description: ATP citrate lyase inhibitor; orally bioavailable
Chemical Name: 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable.

Technical Data

M. Wt 424.3
Formula C19H15Cl2NO4S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 943962-47-8
PubChem ID 90488956
InChI Key LIZVMVYXZWADCK-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(O)C=C1S(NC2=C(C3=CC=CC=C3)C=CC(OC)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.24 10
ethanol 21.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 424.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.71 mL 23.57 mL 47.14 mL
2.5 mM 0.94 mL 4.71 mL 9.43 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Li et al (2007) 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg.Med.Chem.Lett. 17 3208 PMID: 17383874

Ma et al (2009) A novel direct homogeneous assay for ATP citrate lyase. J.Lipid Res. 50 2131 PMID: 19286649


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Keywords: BMS 303141, BMS 303141 supplier, BMS303141, ATP, citrate, lyases, inhibits, inhibitors, plasma, glucose, triglycerides, orally, bioavailable, synthases, transferases, ACLY, Citrate, Lyase, 4609, Tocris Bioscience

2 Citations for BMS 303141

Citations are publications that use Tocris products. Selected citations for BMS 303141 include:

Namgaladze et al (2018) Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase. Front Immunol 9 2858 PMID: 30568658

Shah et al (2016) Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism. Oncotarget 7 43713 PMID: 27248322


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Literature in this Area

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