BIM 23056

Discontinued Product

BIM 23056 (Cat. No. 1844) has been withdrawn from sale for commercial reasons.
Description: sst ligand

Biological Activity for BIM 23056

BIM 23056 is a somatostatin receptor ligand (Ki values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst1 - 5 receptors respectively). Behaves as an antagonist on SRIF14-induced [35S]-GTPγS binding at sst3 and sst5 receptors (PKB values are 6.33 and 5.84 respectively).

Technical Data for BIM 23056

M. Wt 1232.49
Formula C71H81N11O9

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = D-Nal & C-terminal amide)

Storage Desiccate at -20°C
CAS Number 150155-61-6
PubChem ID 16133799
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BIM 23056

Certificate of Analysis / Product Datasheet
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References for BIM 23056

References are publications that support the biological activity of the product.

Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476

Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol.Pharmacol. 43 838 PMID: 8100350

Siehler and Hoyer (1999) Characterisation of human recombinant somatostatin receptors. Modulation of GTPgammaS binding. Naunyn Schmiedebergs Arch.Pharmacol. 360 500 PMID: 10598789

Wilkinson et al (1996) Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 receptor. Br.J.Pharmacol. 118 445 PMID: 8762063

Keywords: BIM 23056, BIM 23056 supplier, Somatostatin, receptor, agonists, Receptors, BIM23056, 1844, Tocris Bioscience

Citations for BIM 23056

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Currently there are no citations for BIM 23056.

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