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Somatostatin receptor ligand (Ki values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst1 - 5 receptors respectively). Behaves as an antagonist on SRIF14-induced [35S]-GTPγS binding at sst3 and sst5 receptors (PKB values are 6.33 and 5.84 respectively).
(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = D-Nal & C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in 20% acetonitrile / water|
References are publications that support the biological activity of the product.
Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476
Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol.Pharmacol. 43 838 PMID: 8100350
Siehler and Hoyer (1999) Characterisation of human recombinant somatostatin receptors. Modulation of GTPgammaS binding. Naunyn Schmiedebergs Arch.Pharmacol. 360 500 PMID: 10598789
Wilkinson et al (1996) Potent antagonism by BIM-23056 at the human recombinant somatostatin sst5 receptor. Br.J.Pharmacol. 118 445 PMID: 8762063
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Keywords: BIM 23056, BIM 23056 supplier, Somatostatin, receptor, agonists, Receptors, BIM23056, 1844, Tocris Bioscience
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