BIM 23052

Discontinued Product

Unfortunately BIM 23052 (Cat. No. 2842) has been withdrawn from sale for commercial reasons.
Cat.No. 2842 - BIM 23052 | D-Phe-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-NH2 | CAS No. 133073-82-2
Description: sst5 agonist
Datasheet
Citations
Literature

Biological Activity

Somatostatin sst5 receptor agonist (Ki values are 7.3, 13.5, 31.3 and 141 nM for sst5, sst2, sst1 and sst4 receptors respectively). Stimulates gastric emptying following i.c. administration.

Technical Data

M. Wt 1122.3
Formula C61H75N11O10
Sequence FFFWKTFT

(Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Thr-8 = C-terminal amide)

Storage Store at -20°C
CAS Number 133073-82-2
PubChem ID 9963480
InChI Key HMTCBXPQKWFOMG-QWXJMLLVSA-N
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1122.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.89 mL 4.46 mL 8.91 mL
5 mM 0.18 mL 0.89 mL 1.78 mL
10 mM 0.09 mL 0.45 mL 0.89 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476

Martinez et al (2000) Intracisternal injection of somatostatin receptor 5-preferring agonists induces a vagal cholinergic stimulation of gastric emptying in rats. J.Pharmacol.Exp.Ther. 293 1099 PMID: 10869415

Nunn et al (2002) Pharmacological characterisation of the goldfish somatostatin sst5 receptor. Eur.J.Pharmacol. 436 173 PMID: 11858797

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Keywords: BIM 23052, supplier, sst5, agonists, Receptors, Somatostatin, BIM23052, Somatostatin, Receptors, Tocris Bioscience

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Cardiovascular

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