Inhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 155.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.44 mL||32.22 mL||64.43 mL|
|5 mM||1.29 mL||6.44 mL||12.89 mL|
|10 mM||0.64 mL||3.22 mL||6.44 mL|
|50 mM||0.13 mL||0.64 mL||1.29 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kim et al (2008) BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol.Pharm.Bull. 31 1096 PMID: 18520037
Lin et al (2004) L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma. Neoplasia 6 74 PMID: 15068672
Fraga et al (2002) L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J.Nutr. 132 733 PMID: 11925469
If you know of a relevant reference for BCH, please let us know.
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Keywords: BCH, supplier, LAT1, L-type, amino, acid, transporters, inhibitors, inhibits, Other, Ion, Pumps/Transporters, Other, Ion, Pumps/Transporters, Tocris Bioscience
Citations for BCH
Citations are publications that use Tocris products.
Currently there are no citations for BCH. Do you know of a great paper that uses BCH from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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