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Description: LAT1 inhibitor
Chemical Name: 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid
Citations (1)

Biological Activity for BCH

BCH is an inhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.

Technical Data for BCH

M. Wt 155.2
Formula C8H13NO2
Storage Store at RT
CAS Number 20448-79-7
PubChem ID 115288
Smiles NC1(C(O)=O)CC2CCC1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BCH

Solvent Max Conc. mg/mL Max Conc. mM
water 15.52 100

Preparing Stock Solutions for BCH

The following data is based on the product molecular weight 155.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.44 mL 32.22 mL 64.43 mL
5 mM 1.29 mL 6.44 mL 12.89 mL
10 mM 0.64 mL 3.22 mL 6.44 mL
50 mM 0.13 mL 0.64 mL 1.29 mL

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Product Datasheets for BCH

Certificate of Analysis / Product Datasheet
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References for BCH

References are publications that support the biological activity of the product.

Kim et al (2008) BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol.Pharm.Bull. 31 1096 PMID: 18520037

Lin et al (2004) L-type amino acid transporter-1 overexpression and melp. sensitivity in Barrett's adenocarcinoma. Neoplasia 6 74 PMID: 15068672

Fraga et al (2002) L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J.Nutr. 132 733 PMID: 11925469

If you know of a relevant reference for BCH, please let us know.

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Keywords: BCH, BCH supplier, LAT1, L-type, amino, acid, transporters, inhibitors, inhibits, Other, Ion, Pumps/Transporters, 5027, Tocris Bioscience

1 Citation for BCH

Citations are publications that use Tocris products. Selected citations for BCH include:

Ying et al (2005) Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br J Pharmacol 146 324-32 PMID: 16041400

Do you know of a great paper that uses BCH from Tocris? Please let us know.

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