Inhibitor of L-type amino acid transporter LAT1. Suppresses growth and induces apoptosis via activation of caspases in KB, Saos2 and C6 cancer cell lines.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 155.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.44 mL||32.22 mL||64.43 mL|
|5 mM||1.29 mL||6.44 mL||12.89 mL|
|10 mM||0.64 mL||3.22 mL||6.44 mL|
|50 mM||0.13 mL||0.64 mL||1.29 mL|
References are publications that support the biological activity of the product.
Kim et al (2008) BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. Biol.Pharm.Bull. 31 1096 PMID: 18520037
Lin et al (2004) L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma. Neoplasia 6 74 PMID: 15068672
Fraga et al (2002) L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J.Nutr. 132 733 PMID: 11925469
If you know of a relevant reference for BCH, please let us know.
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Keywords: BCH, BCH supplier, LAT1, L-type, amino, acid, transporters, inhibitors, inhibits, Other, Ion, Pumps/Transporters, 5027, Tocris Bioscience
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