BAY-u 9773

Discontinued Product

BAY-u 9773 (Cat. No. 3138) has been withdrawn from sale for commercial reasons.
Cat.No. 3138 - BAY-u 9773 | C27H36O5S | CAS No. 154978-38-8
Description: Dual CysLT1 and CysLT2 antagonist
Chemical Name: 4-[[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]thio]benzoic acid
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Cysteinyl leukotriene receptor antagonist with equal affinity at both CysLT1 and CysLT2 receptors (pKB values are 6.8 and 6.5 respectively). Competitive antagonist of LTC4- and LTE4-induced contractions of the guinea pig trachea.

Technical Data

M. Wt 472.64
Formula C27H36O5S
Storage Store at -80°C
CAS Number 154978-38-8
PubChem ID 5311015
InChI Key PKJINWOACFYDQN-RBVMPENBSA-N
Smiles CCCCC\C=C/C/C=C\C=C\C=C\[C@@H](SC1=CC=C(C(O)=O)C=C1)[C@@H](O)CCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Labat et al (1992) A second cysteinyl leukotriene receptor in human lung. J.Pharmacol.Exp.Ther. 263 800 PMID: 1331415

Goranne et al (1996) Cysteinyl leukotriene receptors in the human lung: what's new? TiPS 17 342 PMID: 8979767

Back (2002) Functional characteristics of cysteinyl-leukotriene receptor subtypes. Life Sci. 71 611 PMID: 12072150

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Keywords: BAY-u 9773, BAY-u 9773 supplier, Dual, CysLT1, CysLT2, antagonists, Receptors, leukotrienes, eicosanoids, BAY-u9773, Leukotriene, and, Related, 3138, Tocris Bioscience

1 Citation for BAY-u 9773

Citations are publications that use Tocris products. Selected citations for BAY-u 9773 include:

Wegner et al (2019) Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Elife 8 PMID: 30838976


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