Cysteinyl leukotriene receptor antagonist with equal affinity at both CysLT1 and CysLT2 receptors (pKB values are 6.8 and 6.5 respectively). Competitive antagonist of LTC4- and LTE4-induced contractions of the guinea pig trachea.
|Storage||Store at -80°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in ethanol (supplied pre-dissolved in Ethanol, 0.1mg/ml)|
Preparing Stock Solutions
The following data is based on the product molecular weight 472.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.12 mL||10.58 mL||21.16 mL|
|5 mM||0.42 mL||2.12 mL||4.23 mL|
|10 mM||0.21 mL||1.06 mL||2.12 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References are publications that support the products' biological activity.
Labat et al (1992) A second cysteinyl leukotriene receptor in human lung. J.Pharmacol.Exp.Ther. 263 800 PMID: 1331415
Goranne et al (1996) Cysteinyl leukotriene receptors in the human lung: what's new? TiPS 17 342 PMID: 8979767
Back (2002) Functional characteristics of cysteinyl-leukotriene receptor subtypes. Life Sci. 71 611 PMID: 12072150
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