BAY-u 3405

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Description: Dual TP/DP2 (CRTH2) receptor antagonist
Alternative Names: Ramatroban
Chemical Name: (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity for BAY-u 3405

BAY-u 3405 is a potent dual antagonist of TP/DP2 (CRTH2) prostanoid receptors (Ki values are 4.3, 4.5 and > 10000 nM for hDP2, hTP and hDP1 receptors respectively). Suppresses PGD2-induced migration of human eosinophils (IC50 = 170 nM).

Technical Data for BAY-u 3405

M. Wt 416.47
Formula C21H21FN2O4S
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 116649-85-5
PubChem ID 123879
Smiles FC(C=C4)=CC=C4S(N[C@@H](C3)CCC2=C3C1=CC=CC=C1N2CCC(O)=O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY-u 3405

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.65 100
ethanol 41.65 100

Preparing Stock Solutions for BAY-u 3405

The following data is based on the product molecular weight 416.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12.01 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for BAY-u 3405

Certificate of Analysis / Product Datasheet
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References for BAY-u 3405

References are publications that support the biological activity of the product.

Sundstrom et al (2003) Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J.Pharmacol.Exp.Ther. 307 408 PMID: 12954791

Ishizuka et al (2004) Ramatroban (BAY u3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. Cardiovasc.Drug Rev. 22 71 PMID: 15179446

Ulven and Kostenis (2005) Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J.Med.Chem. 48 897 PMID: 15715457

If you know of a relevant reference for BAY-u 3405, please let us know.

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Keywords: BAY-u 3405, BAY-u 3405 supplier, Dual, TP/DP2, CRTH2, receptors, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, BAY-u3405, Ramatroban, Receptors, 2732, Tocris Bioscience

Citations for BAY-u 3405

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Reviews for BAY-u 3405

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BAY-u 3405 inhibits 15d-PGJ2-induced p38 activation.
By Chintan Koyani on 12/10/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes

HL-1 cardiomyocytes were pre-incubated with BAY-u 3405 (2 µM, 30 min) followed by treatment with 15d-PGJ2 (15 µM, 30 min) to follow p38 activation using Western blot analysis. BAY-u 3405 completely abolished 15d-PGJ2-induced p38 phosphorylation.

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