Home / Pharmacology / Transporters / Ion Pumps/Transporters / Monocarboxylate Transporters / BAY 8002

BAY 8002

Cat. No. 6817 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 6817 - BAY 8002 | C20H14ClNO5S | CAS No. 724440-27-1
Description: Potent dual MCT1/2 inhibitor; orally bioavailable
Chemical Name: 2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BAY 8002

BAY 8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively; IC50 values of human MCT1, MCT2, and MCT4 isoforms recombinantly expressed in X. laevis oocytes are 1, 5 and >500 nM, respectively); suppresses bidirectional lactate transport. Inhibits cellular SNARF-5 fluorescence change (IC50 = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases intratumor lactate levels of Raji tumor xenografts in mice. Orally bioavailable.

Technical Data for BAY 8002

M. Wt 415.85
Formula C20H14ClNO5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 724440-27-1
PubChem ID 992293
InChI Key CLAUJSRBKSRTGQ-UHFFFAOYSA-N
Smiles OC(C1=C(C=CC=C1)NC(C2=C(C=CC(S(=O)(C3=CC=CC=C3)=O)=C2)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 8002

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.58 100

Preparing Stock Solutions for BAY 8002

The following data is based on the product molecular weight 415.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12.02 mL 24.05 mL
5 mM 0.48 mL 2.4 mL 4.81 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for BAY 8002

References are publications that support the biological activity of the product.

Quanz et al (2018) Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistance. Mol.Cancer Ther. 17 2285 PMID: 30115664

If you know of a relevant reference for BAY 8002, please let us know.

View Related Products by Target

Keywords: BAY 8002, BAY 8002 supplier, BAY8002, potent, dual, MCT1/2, inhibitors, inhibits, MCT1, MCT2, orally, bioavailable, lactate, Monocarboxylate, Transporters, 6817, Tocris Bioscience

Citations for BAY 8002

Citations are publications that use Tocris products.

Currently there are no citations for BAY 8002. Do you know of a great paper that uses BAY 8002 from Tocris? Please let us know.

Reviews for BAY 8002

There are currently no reviews for this product. Be the first to review BAY 8002 and earn rewards!

Have you used BAY 8002?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis