BAY 707

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Description: Potent and selective MTH1 inhibitor
Chemical Name: N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for BAY 707

BAY 707 is a potent and selective MTH1 inhibitor (IC50 = 2.3 nM); exhibits no significant activity at 1 μM concentration against a panel of 97 kinases. BAY 707 is cell-permeable and active in vivo, and displays no antitumor activity in vitro or in vivo.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-707 probe summary on the SGC website.

External Portal Information for BAY 707 is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 707 is reviewed on the chemical probes website.

Technical Data for BAY 707

M. Wt 288.34
Formula C15H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2109805-96-9
PubChem ID 129012086
Smiles CCNC(C1=CC2=C(N3CCOC[C@@H]3C)C=CN=C2N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 707

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.83 100
ethanol 2.88 10

Preparing Stock Solutions for BAY 707

The following data is based on the product molecular weight 288.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.34 mL 34.68 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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References for BAY 707

References are publications that support the biological activity of the product.

Rahm et al (2018) Creation of a novel class of potent and selective MutT Homologue 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design. J.Med.Chem. 61 2533 PMID: 29485874

Ellermann et al (2017) Novel class of potent and cellularly active inhibitors devalidates MTH1 as broad-spectrum cancer target. ACS Chem.Biol. 12 1986 PMID: 28679043

If you know of a relevant reference for BAY 707, please let us know.

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Citations for BAY 707

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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