BAY 707

Pricing Availability   Qty
Cat.No. 6562 - BAY 707 | C15H20N4O2 | CAS No. 2109805-96-9
Description: Potent and selective MTH1 inhibitor
Chemical Name: N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

BAY 707 is a potent and selective MTH1 inhibitor (IC50 = 2.3 nM), whicheExhibits no significant activity at 1 μM concentration against a panel of 97 kinases. BAY 707 is cell-permeable and active in vivo, and displays no antitumor activity in vitro or in vivo.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-707 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 707 is reviewed on the chemical probes website.

Technical Data

M. Wt 288.34
Formula C15H20N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2109805-96-9
PubChem ID 129012086
InChI Key RPMGXDCRCWWCRY-JTQLQIEISA-N
Smiles CCNC(C1=CC2=C(N3CCOC[C@@H]3C)C=CN=C2N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.83 100
ethanol 2.88 10

Preparing Stock Solutions

The following data is based on the product molecular weight 288.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.34 mL 34.68 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

Molarity Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Rahm et al (2018) Creation of a novel class of potent and selective MutT Homologue 1 (MTH1) inhibitors using fragment-based screening and structure-based drug design. J.Med.Chem. 61 2533 PMID: 29485874

Ellermann et al (2017) Novel class of potent and cellularly active inhibitors devalidates MTH1 as broad-spectrum cancer target. ACS Chem.Biol. 12 1986 PMID: 28679043


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Citations for BAY 707

Citations are publications that use Tocris products.

Currently there are no citations for BAY 707. Do you know of a great paper that uses BAY 707 from Tocris? Please let us know.

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Cancer Metabolism

Cancer Metabolism Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.

Epigenetics in Cancer

Epigenetics in Cancer Poster

Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.