Novel CB1/CB2 receptor partial agonist (Ki values are 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively). Orally active CB1 agonist in vivo. Displays anti-hyperalgesic and antiallodynic properties in rat models of chronic neuropathic and inflammatory pain.
Sold for research purposes under agreement from Bayer
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 453.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.21 mL||11.03 mL||22.06 mL|
|5 mM||0.44 mL||2.21 mL||4.41 mL|
|10 mM||0.22 mL||1.1 mL||2.21 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References are publications that support the products' biological activity.
De Vry et al (2004) 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid CB1/CB2 receptor partial agonist with antihyperalgesic and antiallodynic effects. J.Pharmacol.Exp.Ther. 310 620 PMID: 15140913
De Vry et al (2004) Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. Eur J Pharmacol. 505 127 PMID: 15556145
If you know of a relevant reference for Bay 59-3074, please let us know.
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Keywords: Bay 59-3074, supplier, CB1/CB2, receptor, partial, agonists, cannabinoids, Non-Selective, Receptors, Bay59-3074, cb2r, cb1r, Non-selective, Cannabinoids, Non-selective, Cannabinoids, Tocris Bioscience
2 Citations for Bay 59-3074
Citations are publications that use Tocris products. Selected citations for Bay 59-3074 include:
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730
McGuinness et al (2009) Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay. Biol Psychiatry 14 49 PMID: 19171920
Do you know of a great paper that uses Bay 59-3074 from Tocris? If so please let us know.
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