Bay 59-3074

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Cat.No. 2500 - Bay 59-3074 | C18H13F6NO4S | CAS No. 406205-74-1
Description: CB1/CB2 receptor partial agonist
Chemical Name: 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl 4,4,4-trifluoro-1-butanesulfonic acid ester
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Novel CB1/CB2 receptor partial agonist (Ki values are 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively). Orally active CB1 agonist in vivo. Displays anti-hyperalgesic and antiallodynic properties in rat models of chronic neuropathic and inflammatory pain.

Licensing Information

Sold for research purposes under agreement from Bayer

Technical Data

M. Wt 453.35
Formula C18H13F6NO4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 406205-74-1
PubChem ID 10479060
InChI Key LWUSZIVDPJPVBW-UHFFFAOYSA-N
Smiles FC(F)(F)CCCS(=O)(=O)OC1=CC(OC2=CC=CC(=C2C#N)C(F)(F)F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.34 100
ethanol 45.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 453.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.03 mL 22.06 mL
5 mM 0.44 mL 2.21 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

De Vry et al (2004) 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid CB1/CB2 receptor partial agonist with antihyperalgesic and antiallodynic effects. J.Pharmacol.Exp.Ther. 310 620 PMID: 15140913

De Vry et al (2004) Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. Eur J Pharmacol. 505 127 PMID: 15556145


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Keywords: CB1/CB2 receptor partial agonists cannabinoids Non-Selective Receptors Bay59-3074 cb2r cb1r Non-selective Cannabinoids

2 Citations for Bay 59-3074

Citations are publications that use Tocris products. Selected citations for Bay 59-3074 include:

McGuinness et al (2009) Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay. Biol Psychiatry 14 49 PMID: 19171920

Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050 PMID: 24048730


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