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Biological Activity for AZ 3451
AZ 3451 is a potent negative allosteric modulator of PAR2 (IC50 = 23 nM); binds to a remote allosteric site outside the helical bundle. Inhibits ERK phosphorylation in 1321N1 cells overexpressing wild-type human PAR2. Highly lipophilic.
Compound Libraries for AZ 3451
Technical Data for AZ 3451
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AZ 3451
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AZ 3451
The following data is based on the product molecular weight 571.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.75 mL||8.75 mL||17.5 mL|
|5 mM||0.35 mL||1.75 mL||3.5 mL|
|10 mM||0.17 mL||0.87 mL||1.75 mL|
|50 mM||0.03 mL||0.17 mL||0.35 mL|
References for AZ 3451
References are publications that support the biological activity of the product.
Cheng et al (2017) Structural insight into allosteric modulation of protease-activated receptor 2. Nature 545 112 PMID: 28445455
If you know of a relevant reference for AZ 3451, please let us know.
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Citations for AZ 3451
Citations are publications that use Tocris products.
Currently there are no citations for AZ 3451. Do you know of a great paper that uses AZ 3451 from Tocris? Please let us know.
Reviews for AZ 3451
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Literature in this Area
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