Selective PAR4 receptor agonist peptide. Stimulates platelet aggregation in vitro (EC50 = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.
(Modifications: Phe-6 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 680.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.47 mL||7.34 mL||14.69 mL|
|5 mM||0.29 mL||1.47 mL||2.94 mL|
|10 mM||0.15 mL||0.73 mL||1.47 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the biological activity of the product.
Faruqi et al (2000) Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. 275 19728 PMID: 10779527
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
Hollenburg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
If you know of a relevant reference for AY-NH2, please let us know.
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Keywords: AY-NH2, AY-NH2 supplier, selective, PAR4, agonists, receptors, protease-activated, proteinase-activated, peptide, AYPGKF-NH2, Protease-Activated, Receptors, 1487, Tocris Bioscience
2 Citations for AY-NH2
Citations are publications that use Tocris products. Selected citations for AY-NH2 include:
Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891
Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Oncogene 21 4852 PMID: 25944998
Do you know of a great paper that uses AY-NH2 from Tocris? Please let us know.
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Literature in this Area
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