AY-NH2

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Cat.No. 1487 - AY-NH2 | Ala-Tyr-Pro-Gly-Lys-Phe-NH2 | CAS No. 352017-71-1
Description: Selective PAR4 agonist
Alternative Names: AYPGKF-NH2
Datasheet
Citations (1)
Literature

Biological Activity

Selective PAR4 receptor agonist peptide. Stimulates platelet aggregation in vitro (EC50 = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.

Technical Data

M. Wt 680.8
Formula C34H48N8O7
Sequence AYPGKF

(Modifications: Phe-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 352017-71-1
PubChem ID 9987061
InChI Key BBAOHIALRKLBRD-OZDPOCAXSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 680.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.34 mL 14.69 mL
5 mM 0.29 mL 1.47 mL 2.94 mL
10 mM 0.15 mL 0.73 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Faruqi et al (2000) Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. 275 19728 PMID: 10779527

Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248

Hollenburg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771


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Keywords: AY-NH2, supplier, selective, PAR4, agonists, receptors, protease-activated, proteinase-activated, peptide, AYPGKF-NH2, Protease-Activated, Receptors, Tocris Bioscience

1 Citation for AY-NH2

Citations are publications that use Tocris products. Selected citations for AY-NH2 include:

Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Oncogene 21 4852 PMID: 25944998


Do you know of a great paper that uses AY-NH2 from Tocris? If so please let us know.

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Pathways for AY-NH2

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