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Description: Selective PAR4 agonist
Alternative Names: AYPGKF-NH2
Purity: ≥95% (HPLC)
Citations (4)

Biological Activity for AY-NH2

AY-NH2 is a selective PAR4 receptor agonist peptide. Stimulates platelet aggregation in vitro (EC50 = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.

Technical Data for AY-NH2

M. Wt 680.8
Formula C34H48N8O7
Sequence AYPGKF

(Modifications: Phe-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 352017-71-1
PubChem ID 9987061
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AY-NH2

Solubility Soluble to 2 mg/ml in water

Product Datasheets for AY-NH2

Certificate of Analysis / Product Datasheet
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References for AY-NH2

References are publications that support the biological activity of the product.

Faruqi et al (2000) Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. J.Biol.Chem. 275 19728 PMID: 10779527

Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248

Hollenburg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771

If you know of a relevant reference for AY-NH2, please let us know.

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Keywords: AY-NH2, AY-NH2 supplier, selective, PAR4, agonists, receptors, protease-activated, proteinase-activated, peptide, AYPGKF-NH2, Protease-Activated, Receptors, 1487, Tocris Bioscience

4 Citations for AY-NH2

Citations are publications that use Tocris products. Selected citations for AY-NH2 include:

de la Fuente et al (2020) Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen-Deuterium Exchange. Biochemistry 59 671 PMID: 31957446

Peng et al (2019) Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function. Front Immunol 10 1311 PMID: 31275306

Shi et al (2015) Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. Oncogene 21 4852 PMID: 25944998

Wang (2017) Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A 114 10948 PMID: 28973891

Do you know of a great paper that uses AY-NH2 from Tocris? Please let us know.

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