Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAY 254
Description: Potent PAR2 biased agonist; exhibits bias for ERK1/2 signaling
Purity: ≥95% (HPLC)
Biological Activity for AY 254
AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.
Technical Data for AY 254
| M. Wt | 631.77 |
| Formula | C30H49N9O6 |
| Sequence |
XXAR (Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, Arg-4 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2093408-03-6 |
| InChI Key | ZVDSAIOSGOWYAW-CKLTXHEASA-N |
| Smiles | O=C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for AY 254
References for AY 254
References are publications that support the biological activity of the product.
Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521
View Related Products by Target
View Related Products by Product Action
Keywords: AY 254, AY 254 supplier, AY254, GPR11, PAR2, potent, proteinase, protease-activated, receptor, 2, biased, agonists, agonism, ERK1/2, signaling, signalling, Protease-Activated, Receptors, 7034, Tocris Bioscience
Citations for AY 254
Citations are publications that use Tocris products.
Currently there are no citations for AY 254.
Reviews for AY 254
There are currently no reviews for this product. Be the first to review AY 254 and earn rewards!
Have you used AY 254?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image