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Submit ReviewAY 254
Description: Potent PAR2 biased agonist; exhibits bias for ERK1/2 signaling
Purity: ≥95% (HPLC)
Biological Activity for AY 254
AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.
Technical Data for AY 254
| M. Wt | 631.77 |
| Formula | C30H49N9O6 |
| Sequence |
XXAR (Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, Arg-4 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2093408-03-6 |
| InChI Key | ZVDSAIOSGOWYAW-CKLTXHEASA-N |
| Smiles | O=C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AY 254
| Solubility | Soluble to 2 mg/ml in 0.1% acetic acid |
Product Datasheets for AY 254
References for AY 254
References are publications that support the biological activity of the product.
Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521
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Citations for AY 254
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