AY 254

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Cat.No. 7034 - AY 254 | 5-Isox-Cha-Chg-Ala-Arg-NH2 | CAS No. 2093408-03-6
Description: Potent PAR2 biased agonist; exhibits bias for ERK1/2 signaling
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.

Technical Data

M. Wt 631.77
Formula C30H49N9O6
Sequence XXAR

(Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, Arg-4 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2093408-03-6
InChI Key ZVDSAIOSGOWYAW-CKLTXHEASA-N
Smiles O=C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in 0.1% acetic acid

References

References are publications that support the biological activity of the product.

Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521


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