AY 254

Discontinued Product

AY 254 (Cat. No. 7034) has been withdrawn from sale for commercial reasons.
Description: Potent PAR2 biased agonist; exhibits bias for ERK1/2 signaling
Purity: ≥95% (HPLC)

Biological Activity for AY 254

AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.

Technical Data for AY 254

M. Wt 631.77
Formula C30H49N9O6
Sequence XXAR

(Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, Arg-4 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2093408-03-6
Smiles O=C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)C1CCCCC1)=O)CC2CCCCC2)C3=CC=NO3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AY 254

References are publications that support the biological activity of the product.

Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521

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Keywords: AY 254, AY 254 supplier, AY254, GPR11, PAR2, potent, proteinase, protease-activated, receptor, 2, biased, agonists, agonism, ERK1/2, signaling, signalling, Protease-Activated, Receptors, 7034, Tocris Bioscience

Citations for AY 254

Citations are publications that use Tocris products.

Currently there are no citations for AY 254.

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