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AY 254 New
Potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). Reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.
(Modifications: X-1 = 5-Isoxazolylcarbonyl-Cha, X-2 = Chg, Arg-4 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in 0.1% acetic acid|
References are publications that support the biological activity of the product.
Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521
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Keywords: AY 254, AY 254 supplier, AY254, GPR11, PAR2, potent, proteinase, protease-activated, receptor, 2, biased, agonists, agonism, ERK1/2, signaling, signalling, Protease-Activated, Receptors, 7034, Tocris Bioscience
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