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Biological Activity for aTAG 2139-NEG
aTAG 2139-NEG is the negative control for aTAG 2139 (Cat. No. 6970).
Technical Data for aTAG 2139-NEG
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for aTAG 2139-NEG
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for aTAG 2139-NEG
The following data is based on the product molecular weight 796.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.25 mL||6.27 mL||12.55 mL|
|5 mM||0.25 mL||1.25 mL||2.51 mL|
|10 mM||0.13 mL||0.63 mL||1.25 mL|
|50 mM||0.03 mL||0.13 mL||0.25 mL|
References for aTAG 2139-NEG
References are publications that support the biological activity of the product.
Veits et al (2021) Development of an AchillesTAG degradation system and its application to control CAR-T activity. Curr.Res.Chem.Biol. 1 100010
If you know of a relevant reference for aTAG 2139-NEG, please let us know.
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Citations for aTAG 2139-NEG
Citations are publications that use Tocris products.
Currently there are no citations for aTAG 2139-NEG. Do you know of a great paper that uses aTAG 2139-NEG from Tocris? Please let us know.
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Protocols for aTAG 2139-NEG
The following protocol features additional information for the use of aTAG 2139-NEG (Cat. No. 7575).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
- Assays for Protein Degradation
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia