Astressin

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Cat.No. 1606 - Astressin | D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-γ-Glu-Ala-His-ε-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2 | CAS No. 170809-51-5
Description: Potent CRF receptor antagonist
Alternative Names: [D-Phe12, Nle21,38, Glu30, Lys33]-CRF (12-41)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent corticotropin-releasing factor (CRF) receptor antagonist (Ki values are 2, 1.5 and 1 nM at CRF1, CRF2α and CRF2β). Reduces ACTH secretion, blocks delayed gastric emptying and is neuroprotective in vivo.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data

M. Wt 3563.2
Formula C161H269N49O42
Sequence FHLLREVLEXARAEQLAQEAHKNRKLXEII

(Modifications: Phe-1 = D-Phe, X = Nle, Glu-19 = γ-Glu, Lys-22 = ε-Lys, Cyclized = Glu-19 -Lys-22, Ile-31 = C-terminal amide)

Storage Store at -20°C
CAS Number 170809-51-5
PubChem ID 16133798
InChI Key HPYIIXJJVYSMCV-MGDXKYBTSA-N
Smiles [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC=N2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in 10% Acetic acid / water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Gulyas et al (1995) Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc.Natl.Acad.Sci.U.S.A. 92 10575 PMID: 7479843

Maecker et al (1997) Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure. Brain Res. 744 166 PMID: 9030428

Martinez et al (1999) Peripheral injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. J.Pharmacol.Exp.Ther. 290 629 PMID: 10411571

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312 PMID: 10816663


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Keywords: Astressin, Astressin supplier, Potent, CRF, receptor, antagonists, Corticotropin-Releasing, Factor, Non-Selective, Receptors, [D-Phe12,, Nle21,38,, Glu30,, Lys33]-CRF, (12-41), Non-selective, 1606, Tocris Bioscience

Citations for Astressin

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