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Selective free fatty acid receptor 1 (FFA1/GPR40) agonist. Exhibits selectivity for GPR40 over GPR41, GPR43, GPR119, GPR120 and PPARγ. Induces glucose-dependent insulin secretion in pancreatic MIN6 cells and in vivo. Enhances insulin sensitivity in a type 2 diabetes model in vivo. Orally available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 448.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.46 mL||22.3 mL||44.59 mL|
|2.5 mM||0.89 mL||4.46 mL||8.92 mL|
|5 mM||0.45 mL||2.23 mL||4.46 mL|
|25 mM||0.09 mL||0.45 mL||0.89 mL|
References are publications that support the biological activity of the product.
Tanaka et al (2013) Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent Ins secretion. J.Pharmacol.Exp.Ther. 346 443 PMID: 23853170
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Keywords: AS 2034178, AS 2034178 supplier, AS2034178, selective, free, fatty, acid, receptors, FFA1, GPR40, agonists, diabetes, insulin, sensitivity, FFAR1, Free, Fatty, Acid, Receptors, 5035, Tocris Bioscience
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