AS 2034178

Pricing Availability Delivery Time Qty
Cat.No. 5035 - AS 2034178 | C27H29FN2O3 | CAS No. 1030846-42-4
Description: Selective FFA1 (GPR40) agonist
Chemical Name: 2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]benzenepropanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective free fatty acid receptor 1 (FFA1/GPR40) agonist. Exhibits selectivity for GPR40 over GPR41, GPR43, GPR119, GPR120 and PPARγ. Induces glucose-dependent insulin secretion in pancreatic MIN6 cells and in vivo. Enhances insulin sensitivity in a type 2 diabetes model in vivo. Orally available.

Compound Libraries

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Technical Data

M. Wt 448.53
Formula C27H29FN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1030846-42-4
PubChem ID 24808572
InChI Key VENOXIKBBUVHRY-UHFFFAOYSA-N
Smiles FC1=C(CCC(O)=O)C=CC(NCC2=C(CCCN3CCOC4=CC=CC=C4)C3=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.43 50
ethanol 8.97 20

Preparing Stock Solutions

The following data is based on the product molecular weight 448.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.15 mL 22.3 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tanaka et al (2013) Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion. J.Pharmacol.Exp.Ther. 346 443 PMID: 23853170


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GPCR

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Pathways for AS 2034178

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