AS 2031477

Discontinued Product

AS 2031477 (Cat. No. 5035) has been withdrawn from sale for commercial reasons.
Description: Selective FFA1 (GPR40) agonist
Chemical Name: 2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]benzenepropanoic acid
Purity: ≥98% (HPLC)

Biological Activity for AS 2031477

AS 2034178 is a selective free fatty acid receptor 1 (FFA1/GPR40) agonist. Exhibits selectivity for GPR40 over GPR41, GPR43, GPR119, GPR120 and PPARγ. Induces glucose-dependent insulin secretion in pancreatic MIN6 cells and in vivo. Enhances insulin sensitivity in a type 2 diabetes model in vivo. Orally available.

Technical Data for AS 2031477

M. Wt 448.53
Formula C27H29FN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1030846-42-4
PubChem ID 24808572

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AS 2031477

References are publications that support the biological activity of the product.

Tanaka et al (2013) Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent Ins secretion. J.Pharmacol.Exp.Ther. 346 443 PMID: 23853170

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Keywords: AS 2031477, AS 2031477 supplier, AS, 2031477, selective, free, fatty, acid, receptors, FFA1, GPR40, agonists, diabetes, insulin, sensitivity, FFAR1, Free, Fatty, Acid, Receptors, 5035, Tocris Bioscience

Citations for AS 2031477

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Currently there are no citations for AS 2031477.

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