AS 2034178

Pricing Availability   Qty
Cat.No. 5035 - AS 2034178 | C27H29FN2O3 | CAS No. 1030846-42-4
Description: Selective FFA1 (GPR40) agonist
Chemical Name: 2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]benzenepropanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective free fatty acid receptor 1 (FFA1/GPR40) agonist. Exhibits selectivity for GPR40 over GPR41, GPR43, GPR119, GPR120 and PPARγ. Induces glucose-dependent insulin secretion in pancreatic MIN6 cells and in vivo. Enhances insulin sensitivity in a type 2 diabetes model in vivo. Orally available.

Compound Libraries

AS 2034178 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 448.53
Formula C27H29FN2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1030846-42-4
PubChem ID 24808572
InChI Key VENOXIKBBUVHRY-UHFFFAOYSA-N
Smiles FC1=C(CCC(O)=O)C=CC(NCC2=C(CCCN3CCOC4=CC=CC=C4)C3=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.43 50
ethanol 8.97 20

Preparing Stock Solutions

The following data is based on the product molecular weight 448.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.46 mL 22.3 mL 44.59 mL
2.5 mM 0.89 mL 4.46 mL 8.92 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
25 mM 0.09 mL 0.45 mL 0.89 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Tanaka et al (2013) Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion. J.Pharmacol.Exp.Ther. 346 443 PMID: 23853170


If you know of a relevant reference for AS 2034178, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Free Fatty Acid Receptor Agonists

Keywords: AS 2034178, AS 2034178 supplier, AS2034178, selective, free, fatty, acid, receptors, FFA1, GPR40, agonists, diabetes, insulin, sensitivity, FFAR1, Free, Fatty, Acid, Receptors, 5035, Tocris Bioscience

Citations for AS 2034178

Citations are publications that use Tocris products.

Currently there are no citations for AS 2034178. Do you know of a great paper that uses AS 2034178 from Tocris? Please let us know.

Reviews for AS 2034178

There are currently no reviews for this product. Be the first to review AS 2034178 and earn rewards!

Have you used AS 2034178?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling