ARN 14494

Pricing Availability   Qty
Description: Potent serine palmitoyltransferase inhibitor
Chemical Name: rel-1-[1-[2-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for ARN 14494

ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

Technical Data for ARN 14494

M. Wt 424.55
Formula C24H32N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1037834-43-7
PubChem ID 24857490
Smiles [H][C@@]12CCC[C@@]1(CN(C(CN3CCC(N4C(CC5=CC(C(NC)=O)=CC=C45)=O)CC3)=O)C2)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ARN 14494

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.12 5
ethanol 21.23 50

Preparing Stock Solutions for ARN 14494

The following data is based on the product molecular weight 424.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.71 mL 23.55 mL 47.11 mL
2.5 mM 0.94 mL 4.71 mL 9.42 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

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References for ARN 14494

References are publications that support the biological activity of the product.

De Vita et al (2019) Inhibition of serine palmitoyltransferase by a small organic molecule promotes neuronal survival after astrocyte amyloid beta 1-42 injury. ACS Chem.Neurosci. 10 1627 PMID: 30481470

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Keywords: ARN 14494, ARN 14494 supplier, ARN14494, serine, palmitoyltransferase, inhibitors, inhibits, potent, Alzheimer, disease, ceramides, Other, Transferases, 7134, Tocris Bioscience

Citations for ARN 14494

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