Arcaine sulfate

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Cat.No. 0389 - Arcaine sulfate | C6H16N6.H2SO4 | CAS No. 14923-17-2
Description: Competitive NMDA antagonist
Chemical Name: N,N'-1,4-Butanediylbisguanidine sulfate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

NO synthase inhibitor. An NMDA antagonist acting as a competitive inhibitor at the polyamine site.

Technical Data

M. Wt 270.31
Formula C6H16N6.H2SO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 14923-17-2
PubChem ID 119020
InChI Key RWTGFMPOODRXIM-UHFFFAOYSA-N
Smiles O=[SH2]([O])O[O].NC(NCCCCNC(N)=N)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 25 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 270.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 36.99 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386 PMID: 9641557

Reynolds (1990) Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. Eur.J.Pharmacol. 177 215 PMID: 2155812

Yokoi et al (1994) Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain. Neuropharmacology 33 1261 PMID: 7532812


If you know of a relevant reference for Arcaine sulfate, please let us know.

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Keywords: Competitive NMDA antagonists Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors

Citations for Arcaine sulfate

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