You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
AR-C 141990 hydrochloride
Biological Activity for AR-C 141990 hydrochloride
AR-C 141990 hydrochloride is a monocarboxylate transporter (MCT1) inhibitor (pKi = 7.6. Exhibits approximately 10-fold selectivity for MCT1 over MCT2 and no significant activity against MCT3 or 4. Inhibits graft versus host response and prolongs cardiac graft survival in a rat model. Immunosuppressant. Also inhibits brain penetration of GHB analog HOCPCA.
Technical Data for AR-C 141990 hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AR-C 141990 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AR-C 141990 hydrochloride
The following data is based on the product molecular weight 529.05. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.89 mL||9.45 mL||18.9 mL|
|5 mM||0.38 mL||1.89 mL||3.78 mL|
|10 mM||0.19 mL||0.95 mL||1.89 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
Product Datasheets for AR-C 141990 hydrochloride
References for AR-C 141990 hydrochloride
References are publications that support the biological activity of the product.
Påhlman et al (2012) Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1. Transpl.Int. 26 22 PMID: 23137339
Thiesen et al (2015) In vitro and in vivo evidence for active brain uptake of the GHB analog HOCPCA by the monocarboxylate transporter subtype 1. J.Pharmacol.Exp.Ther. 354 166 PMID: 25986445
If you know of a relevant reference for AR-C 141990 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: AR-C 141990 hydrochloride, AR-C 141990 hydrochloride supplier, AR-C141990, HCl, monocarboxylate, transporter, 1, MCT1, immunosuppressant, graft, versus, host, GvH, transplant, Monocarboxylate, Transporters, 5658, Tocris Bioscience
Citations for AR-C 141990 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for AR-C 141990 hydrochloride. Do you know of a great paper that uses AR-C 141990 hydrochloride from Tocris? Please let us know.
Reviews for AR-C 141990 hydrochloride
There are currently no reviews for this product. Be the first to review AR-C 141990 hydrochloride and earn rewards!
Have you used AR-C 141990 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Research Product GuideNew
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Tricarboxylic Acid Cycle
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.