APcK 110

Discontinued Product

APcK 110 (Cat. No. 3704) has been withdrawn from sale for commercial reasons.
Cat.No. 3704 - APcK 110 | C20H16FN3O2 | CAS No. 1001083-74-4
Description: KIT inhibitor
Chemical Name: 6-(3,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

KIT inhibitor; inhibits phosphorylation of KIT, STAT3, STAT5 and Akt. Suppresses proliferation of OCI/AML3 cells (IC50 = 175 nM). Caspase-dependant apoptosis inducer.

Compound Libraries

APcK 110 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 349.36
Formula C20H16FN3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1001083-74-4
PubChem ID 24786010
InChI Key CAMGZGMEPKFVMF-UHFFFAOYSA-N
Smiles FC(C=C3)=CC=C3C1=NNC2=C1C=CC(C4=CC(OC)=CC(OC)=C4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Faderl et al (2009) Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer Res. 69 3910 PMID: 19383925

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Keywords: APcK 110, APcK 110 supplier, APcK110, Kit, inhibitors, inhibits, Other, RTKs, 3704, Tocris Bioscience

Citations for APcK 110

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