AMG 18 hydrochloride

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Cat.No. 6166 - AMG 18 hydrochloride | C31H29ClN6O3S.HCl
Description: Potent and selective IRE1α inhibitor
Chemical Name: 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.

Technical Data

M. Wt 637.58
Formula C31H29ClN6O3S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles CC1=C(C2=C(C(NS(=O)(C3=C(C=CC=C3)Cl)=O)=CC=C2)C=C1)OC4=C(C5=NC(N[C@H]6CCCNC6)=NC=C5)C=CC=N4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 63.76 100
DMSO 63.76 100

Preparing Stock Solutions

The following data is based on the product molecular weight 637.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.57 mL 7.84 mL 15.68 mL
5 mM 0.31 mL 1.57 mL 3.14 mL
10 mM 0.16 mL 0.78 mL 1.57 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID: 25589933


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Citations for AMG 18 hydrochloride

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Literature in this Area

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