AMG 18 hydrochlorideNew
Potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 637.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.57 mL||7.84 mL||15.68 mL|
|5 mM||0.31 mL||1.57 mL||3.14 mL|
|10 mM||0.16 mL||0.78 mL||1.57 mL|
|50 mM||0.03 mL||0.16 mL||0.31 mL|
References are publications that support the biological activity of the product.
Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID: 25589933
If you know of a relevant reference for AMG 18 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: AMG 18 hydrochloride, AMG 18 hydrochloride supplier, AMG18, HCl, Potent, IRE1alpha, inhibitors, inhibits, selective, IRE1, IRE, endonuclease, unfolded, protein, response, inositol, requiring, enzyme, 1, 6166, Tocris Bioscience
Citations for AMG 18 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for AMG 18 hydrochloride. Do you know of a great paper that uses AMG 18 hydrochloride from Tocris? Please let us know.
Reviews for AMG 18 hydrochloride
There are currently no reviews for this product. Be the first to review AMG 18 hydrochloride and earn rewards!
Have you used AMG 18 hydrochloride?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)New
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells