AM 4668

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Cat.No. 5789 - AM 4668 | C24H19F3O4S | CAS No. 1011531-27-3
Description: Potent FFA1 (GPR40) agonist
Chemical Name: (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for AM 4668

AM 4668 is a potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.

Technical Data for AM 4668

M. Wt 488.48
Formula C24H19F3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1011531-27-3
PubChem ID 24897670
Smiles CC1=C(COC2=CC=C(C=C2)[C@H](CC(O)=O)C2=NOC=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AM 4668

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 48.85 100
ethanol 48.85 100

Preparing Stock Solutions for AM 4668

The following data is based on the product molecular weight 488.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.24 mL 20.47 mL
5 mM 0.41 mL 2.05 mL 4.09 mL
10 mM 0.2 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References for AM 4668

References are publications that support the biological activity of the product.

Liu et al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517 PMID: 24900872

If you know of a relevant reference for AM 4668, please let us know.

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Citations for AM 4668

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