AM 4668
Biological Activity
Potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.
Technical Data
| M. Wt | 488.48 |
| Formula | C24H19F3O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1011531-27-3 |
| PubChem ID | 24897670 |
| InChI Key | BMLGZNVPWRUVNM-IBGZPJMESA-N |
| Smiles | CC1=C(COC2=CC=C(C=C2)[C@H](CC(O)=O)C2=NOC=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.85 | 100 | |
| ethanol | 48.85 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 488.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.24 mL | 20.47 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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References
References are publications that support the products' biological activity.
Liu et al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517 PMID: 4900872
If you know of a relevant reference for AM 4668, please let us know.
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Keywords: AM4668 free fatty acid receptors FFA1 FFAR agonists agonism type 2 diabetes potent orally bioavailable Free Fatty Acid Receptors
Citations for AM 4668
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