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Submit ReviewAM 4668
Description: Potent FFA1 (GPR40) agonist
Chemical Name: (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid
Purity: ≥98% (HPLC)
Biological Activity for AM 4668
AM 4668 is a potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.
Technical Data for AM 4668
| M. Wt | 488.48 |
| Formula | C24H19F3O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1011531-27-3 |
| PubChem ID | 24897670 |
| InChI Key | BMLGZNVPWRUVNM-IBGZPJMESA-N |
| Smiles | CC1=C(COC2=CC=C(C=C2)[C@H](CC(O)=O)C2=NOC=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AM 4668
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.85 | 100 | |
| ethanol | 48.85 | 100 |
Preparing Stock Solutions for AM 4668
The following data is based on the product molecular weight 488.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.24 mL | 20.47 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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Product Datasheets for AM 4668
References for AM 4668
References are publications that support the biological activity of the product.
Liu et al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517 PMID: 24900872
If you know of a relevant reference for AM 4668, please let us know.
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Citations for AM 4668
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