AM 4668

Cat. No. 5789 Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Bulk Orders

Cat.No. 5789 - AM 4668 | C24H19F3O4S | CAS No. 1011531-27-3

Description: Potent FFA1 (GPR40) agonist

Chemical Name: (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent FFA1 (GPR40) agonist (EC₅₀ = 3.6 nM in an IP₃ assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.

Technical Data

M. Wt	488.48
Formula	C₂₄H₁₉F₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1011531-27-3
PubChem ID	24897670
InChI Key	BMLGZNVPWRUVNM-IBGZPJMESA-N
Smiles	CC1=C(COC2=CC=C(C=C2)[C@H](CC(O)=O)C2=NOC=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	48.85	100
	DMSO	48.85	100

Preparing Stock Solutions

The following data is based on the product molecular weight 488.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.24 mL	20.47 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.2 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.2 mL	0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the biological activity of the product.

Liu et al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517 PMID: 24900872

If you know of a relevant reference for AM 4668, please let us know.

View Related Products by Target

Free Fatty Acid Receptors

View Related Products by Product Action

View all Free Fatty Acid Receptor Agonists

Keywords: AM 4668, AM 4668 supplier, AM4668, free, fatty, acid, receptors, FFA1, FFAR, agonists, agonism, type, 2, diabetes, potent, orally, bioavailable, Free, Fatty, Acid, Receptors, 5789, Tocris Bioscience

Citations for AM 4668

Citations are publications that use Tocris products.

Currently there are no citations for AM 4668. Do you know of a great paper that uses AM 4668 from Tocris? Please let us know.

Reviews for AM 4668

There are currently no reviews for this product. Be the first to review AM 4668 and earn rewards!

Have you used AM 4668?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

Rhodopsin-like Receptors
Secretin-like Receptors
Glutamate Receptors
Frizzled Receptors
GPCR Signaling