AM 4668

Discontinued Product

AM 4668 (Cat. No. 5789) has been withdrawn from sale for commercial reasons.
Description: Potent FFA1 (GPR40) agonist
Chemical Name: (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid
Purity: ≥98% (HPLC)

Biological Activity for AM 4668

AM 4668 is a potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.

Technical Data for AM 4668

M. Wt 488.48
Formula C24H19F3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1011531-27-3
PubChem ID 24897670
Smiles CC1=C(COC2=CC=C(C=C2)[C@H](CC(O)=O)C2=NOC=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AM 4668

References are publications that support the biological activity of the product.

Liu et al (2014) Optimization of GPR40 agonists for type 2 diabetes. ACS Med.Chem.Lett. 5 517 PMID: 24900872

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Citations for AM 4668

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Currently there are no citations for AM 4668.

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