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Cat.No. 0485 - Alrestatin | C14H9NO4 | CAS No. 51411-04-2
Description: Aldose reductase inhibitor
Chemical Name: 1,3-Dioxo-1H-benz[d,e]isoquinoline-2(3H)-acetic acid
Citations (3)

Biological Activity

Specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.

Technical Data

M. Wt 255.23
Formula C14H9NO4
Storage Store at RT
CAS Number 51411-04-2
PubChem ID 2120
Smiles OC(=O)CN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 255.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.59 mL 39.18 mL
5 mM 0.78 mL 3.92 mL 7.84 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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References are publications that support the biological activity of the product.

Barski et al (1996) The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 35 14276 PMID: 8916913

Ehrig et al (1994) Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry 33 7157 PMID: 8003482

Lavrentyev et al (2007) Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 101 455 PMID: 17626897

If you know of a relevant reference for Alrestatin, please let us know.

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Keywords: Alrestatin, Alrestatin supplier, Aldose, reductases, inhibitors, inhibits, Carbohydrate, Metabolism, Reductase, 0485, Tocris Bioscience

3 Citations for Alrestatin

Citations are publications that use Tocris products. Selected citations for Alrestatin include:

Mochin et al (2015) Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. PLoS One 97 55 PMID: 25283348

Lavrentyev and Malik (2009) High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am J Physiol Heart Circ Physiol 296 H106 PMID: 18978194

Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98 PMID: 22654757

Do you know of a great paper that uses Alrestatin from Tocris? Please let us know.

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