Specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 255.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.92 mL||19.59 mL||39.18 mL|
|5 mM||0.78 mL||3.92 mL||7.84 mL|
|10 mM||0.39 mL||1.96 mL||3.92 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
References are publications that support the products' biological activity.
Barski et al (1996) The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 35 14276 PMID: 8916913
Ehrig et al (1994) Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry 33 7157 PMID: 8003482
Lavrentyev et al (2007) Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 101 455 PMID: 17626897
If you know of a relevant reference for Alrestatin, please let us know.
View Related Products by Product Action
Keywords: Alrestatin, supplier, Aldose, reductases, inhibitors, inhibits, Carbohydrate, Metabolism, Aldose, Reductase, Aldose, Reductase, Tocris Bioscience
3 Citations for Alrestatin
Citations are publications that use Tocris products. Selected citations for Alrestatin include:
Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98 PMID: 22654757
Mochin et al (2015) Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. PLoS One 97 55 PMID: 25283348
Lavrentyev and Malik (2009) High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am J Physiol Heart Circ Physiol 296 H106 PMID: 18978194
Do you know of a great paper that uses Alrestatin from Tocris? If so please let us know.
Reviews for Alrestatin
There are currently no reviews for this product. Be the first to review Alrestatin and earn rewards!
Have you used Alrestatin?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
New Product Guide (Spring/Summer 2017)
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells