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Alprostadil is a prostaglandin with some selectivity for EP3 and EP4 receptors (Ki values are 1.1, 2.1, 36, 10 and 33 nM for mouse EP3, EP4, EP1, EP2 and IP receptors respectively). Inhibits platelet aggregation and is a vasodilator in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 354.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.64 mL||28.21 mL||56.42 mL|
|2.5 mM||1.13 mL||5.64 mL||11.28 mL|
|5 mM||0.56 mL||2.82 mL||5.64 mL|
|25 mM||0.11 mL||0.56 mL||1.13 mL|
References are publications that support the biological activity of the product.
Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217 PMID: 9313928
Kirtland (1988) Prostaglandin E1: a review. Prostaglandins Leukot.Essent.Fatty Acids 32 165 PMID: 2901111
Whittle et al (1985) Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. Adv.Exp.Med.Biol. 192 109 PMID: 2871707
If you know of a relevant reference for Alprostadil, please let us know.
Keywords: Alprostadil, Alprostadil supplier, Prostaglandin, Vasodilator, anti-platelet, agent, vivo, Receptors, TP, EP1, EP2, EP3, EP4, Prostanoid, prostaglandins, prostacyclins, eicosanoids, PGE1, E1, 1620, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Alprostadil include:
Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.