Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Prostaglandin. Vasodilator and antiplatelet agent in vivo
Alternative Names: PGE1,Prostaglandin E1
Chemical Name: (11α,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Alprostadil

Alprostadil is a prostaglandin with some selectivity for EP3 and EP4 receptors (Ki values are 1.1, 2.1, 36, 10 and 33 nM for mouse EP3, EP4, EP1, EP2 and IP receptors respectively). Inhibits platelet aggregation and is a vasodilator in vivo.

Technical Data for Alprostadil

M. Wt 354.49
Formula C20H34O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 745-65-3
PubChem ID 5280723
Smiles CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Alprostadil

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 17.72 50

Preparing Stock Solutions for Alprostadil

The following data is based on the product molecular weight 354.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.64 mL 28.21 mL 56.42 mL
2.5 mM 1.13 mL 5.64 mL 11.28 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
25 mM 0.11 mL 0.56 mL 1.13 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Alprostadil

Certificate of Analysis / Product Datasheet
Select another batch:

References for Alprostadil

References are publications that support the biological activity of the product.

Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217 PMID: 9313928

Kirtland (1988) Prostaglandin E1: a review. Prostaglandins Leukot.Essent.Fatty Acids 32 165 PMID: 2901111

Whittle et al (1985) Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. Adv.Exp.Med.Biol. 192 109 PMID: 2871707

If you know of a relevant reference for Alprostadil, please let us know.

View Related Products by Target

Keywords: Alprostadil, Alprostadil supplier, Prostaglandin, Vasodilator, anti-platelet, agent, vivo, Receptors, TP, EP1, EP2, EP3, EP4, Prostanoid, prostaglandins, prostacyclins, eicosanoids, PGE1, E1, 1620, Tocris Bioscience

1 Citation for Alprostadil

Citations are publications that use Tocris products. Selected citations for Alprostadil include:

Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882

Do you know of a great paper that uses Alprostadil from Tocris? Please let us know.

Reviews for Alprostadil

There are currently no reviews for this product. Be the first to review Alprostadil and earn rewards!

Have you used Alprostadil?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review