Alprostadil

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Description: Prostaglandin. Vasodilator and antiplatelet agent in vivo
Alternative Names: PGE1,Prostaglandin E1
Chemical Name: (11α,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Alprostadil

Alprostadil is a prostaglandin with some selectivity for EP3 and EP4 receptors (Ki values are 1.1, 2.1, 36, 10 and 33 nM for mouse EP3, EP4, EP1, EP2 and IP receptors respectively). Inhibits platelet aggregation and is a vasodilator in vivo.

Technical Data for Alprostadil

M. Wt 354.49
Formula C20H34O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 745-65-3
PubChem ID 5280723
InChI Key GMVPRGQOIOIIMI-DWKJAMRDSA-N
Smiles CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Alprostadil

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 17.72 50

Preparing Stock Solutions for Alprostadil

The following data is based on the product molecular weight 354.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.64 mL 28.21 mL 56.42 mL
2.5 mM 1.13 mL 5.64 mL 11.28 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
25 mM 0.11 mL 0.56 mL 1.13 mL

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Product Datasheets for Alprostadil

Certificate of Analysis / Product Datasheet
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References for Alprostadil

References are publications that support the biological activity of the product.

Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217 PMID: 9313928

Kirtland (1988) Prostaglandin E1: a review. Prostaglandins Leukot.Essent.Fatty Acids 32 165 PMID: 2901111

Whittle et al (1985) Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. Adv.Exp.Med.Biol. 192 109 PMID: 2871707


If you know of a relevant reference for Alprostadil, please let us know.

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Keywords: Alprostadil, Alprostadil supplier, Prostaglandin, Vasodilator, anti-platelet, agent, vivo, Receptors, TP, EP1, EP2, EP3, EP4, Prostanoid, prostaglandins, prostacyclins, eicosanoids, PGE1, E1, 1620, Tocris Bioscience

1 Citation for Alprostadil

Citations are publications that use Tocris products. Selected citations for Alprostadil include:

Bisikirska et al (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76 664 PMID: 26589882


Do you know of a great paper that uses Alprostadil from Tocris? Please let us know.

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