Alprostadil

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Cat.No. 1620 - Alprostadil | C20H34O5 | CAS No. 745-65-3
Description: Prostaglandin. Vasodilator and antiplatelet agent in vivo
Alternative Names: PGE1, Prostaglandin E1
Chemical Name: (11α,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Prostaglandin with some selectivity for EP3 and EP4 receptors (Ki values are 1.1, 2.1, 36, 10  and 33 nM for mouse EP3, EP4, EP1, EP2 and IP receptors respectively). Inhibits platelet aggregation and is a vasodilator in vivo.

Technical Data

M. Wt 354.49
Formula C20H34O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 745-65-3
PubChem ID 5280723
InChI Key GMVPRGQOIOIIMI-DWKJAMRDSA-N
Smiles CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.45 100
ethanol 17.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 354.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.1 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217 PMID: 9313928

Kirtland (1988) Prostaglandin E1: a review. Prostaglandins Leukot.Essent.Fatty Acids 32 165 PMID: 2901111

Whittle et al (1985) Specificity between the anti-aggregatory actions of prostacyclin, prostaglandin E1 and D2 on platelets. Adv.Exp.Med.Biol. 192 109 PMID: 2871707


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View Related Products by Target

Keywords: Prostaglandin Vasodilator anti-platelet agent vivo Receptors TP EP1 EP2 EP3 EP4 Prostanoid prostaglandins prostacyclins eicosanoids PGE1 PGE1 Prostaglandin E1 Prostanoid Receptors

Citations for Alprostadil

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Literature in this Area

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Pathways for Alprostadil

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