[Ala92]-p16 (84-103)

Pricing Availability   Qty
Cat.No. 1902 - [Ala92]-p16 (84-103) | Asp-Ala-Ala-Arg-Glu-Gly-Phe-Leu-Ala-Thr-Leu-Val-Val-Leu-His-Arg-Ala-Gly-Ala-Arg | CAS No. 189064-08-2
Description: Cdk inhibitor
Literature (4)

Biological Activity

Peptide derived from the tumor suppressor protein p16; inhibits cyclin-dependent kinase-4 (cdk4)/cyclin D1 (IC50 ~ 1.5 μM) and binds to cdk6.

Technical Data

M. Wt 2123.44
Formula C93H155N31O26
Storage Desiccate at -20°C
CAS Number 189064-08-2
PubChem ID 71308539
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water


References are publications that support the biological activity of the product.

Fahraeus et al (1998) Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule. Oncogene 16 587 PMID: 9482104

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Keywords: [Ala92]-p16 (84-103), [Ala92]-p16 (84-103) supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdks, Kinase, 1902, Tocris Bioscience

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