Peptide derived from the tumor suppressor protein p16; inhibits cyclin-dependent kinase-4 (cdk4)/cyclin D1 (IC50 ~ 1.5 μM) and binds to cdk6.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 2123.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.47 mL||2.35 mL||4.71 mL|
|5 mM||0.09 mL||0.47 mL||0.94 mL|
|10 mM||0.05 mL||0.24 mL||0.47 mL|
|50 mM||0.01 mL||0.05 mL||0.09 mL|
References are publications that support the products' biological activity.
Fahraeus et al (1998) Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule. Oncogene 16 587 PMID: 9482104
If you know of a relevant reference for [Ala92]-p16 (84-103), please let us know.
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Keywords: [Ala92]-p16 (84-103), supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdks, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.