Peptide derived from the tumor suppressor protein p16; inhibits cyclin-dependent kinase-4 (cdk4)/cyclin D1 (IC50 ~ 1.5 μM) and binds to cdk6.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 2123.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.47 mL||2.35 mL||4.71 mL|
|5 mM||0.09 mL||0.47 mL||0.94 mL|
|10 mM||0.05 mL||0.24 mL||0.47 mL|
|50 mM||0.01 mL||0.05 mL||0.09 mL|
References are publications that support the products' biological activity.
Fahraeus et al (1998) Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule. Oncogene 16 587 PMID: 9482104
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Keywords: [Ala92]-p16 (84-103), supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdks, Cyclin-dependent, Kinase, Cyclin-dependent, Kinase, Tocris Bioscience
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