Ailanthone

Discontinued Product

Ailanthone (Cat. No. 6161) has been withdrawn from sale for commercial reasons.
Cat.No. 6161 - Ailanthone | C20H24O7 | CAS No. 981-15-7
Description: Potent inhibitor of androgen receptor (AR)
Chemical Name: (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for Ailanthone

Ailanthone is a potent androgen receptor (AR) inhibitor (IC50 = 69 nM). Disrupts the AR-chaperone complex by binding p23 and blocking AR interaction with HSP90 causing UPS degradation of AR. Inhibits Huh7 cancer cell growth via G0/G1 cell cycle arrest and apoptosis in vitro and in vivo. Inhibits growth and metastasis of certain prostate cancer cell lines. Orally bioavailable.

Technical Data for Ailanthone

M. Wt 376.4
Formula C20H24O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 981-15-7
PubChem ID 72965
InChI Key WBBVXGHSWZIJST-RLQYZCPESA-N
Smiles C=C1[C@]([C@]([C@]2([H])[C@@]3(O)[C@@H]1O)(CO3)[C@@](O4)([H])C[C@@]([C@]2(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Ailanthone

References are publications that support the biological activity of the product.

He et al (2015) Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat.Commun. 7 13122 PMID: 27959342

Zhuo et al (2015) Ailanthone inhibits Huh7 cancer cell growth via cell cycle arrest and apoptosis in vitro and in vivo. Sci.Rep. 5 16185 PMID: 26525771

View Related Products by Target

View Related Products by Product Action

View all Androgen Receptor Inhibitors

Keywords: Ailanthone, Ailanthone supplier, Inhibitors, Inhibits, AR, Androgen, Receptor, p23, HSP90, Ubiquitin, Protease, System, UPS, apoptosis, prostate, cancer, Huh7, CRPC, castration-resistant, 6161, Tocris Bioscience

Citations for Ailanthone

Citations are publications that use Tocris products.

Currently there are no citations for Ailanthone.

Reviews for Ailanthone

There are currently no reviews for this product. Be the first to review Ailanthone and earn rewards!

Have you used Ailanthone?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors