Ailanthone

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Cat.No. 6161 - Ailanthone | C20H24O7 | CAS No. 981-15-7
Description: Potent inhibitor of androgen receptor (AR)
Chemical Name: (1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent androgen receptor (AR) inhibitor (IC50 = 69 nM). Disrupts the AR-chaperone complex by binding p23 and blocking AR interaction with HSP90 causing UPS degradation of AR. Inhibits Huh7 cancer cell growth via G0/G1 cell cycle arrest and apoptosis in vitro and in vivo. Inhibits growth and metastasis of certain prostate cancer cell lines. Orally bioavailable.

Technical Data

M. Wt 376.4
Formula C20H24O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 981-15-7
PubChem ID 72965
InChI Key WBBVXGHSWZIJST-RLQYZCPESA-N
Smiles C=C1[C@]([C@]([C@]2([H])[C@@]3(O)[C@@H]1O)(CO3)[C@@](O4)([H])C[C@@]([C@]2(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 376.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.28 mL 26.57 mL
5 mM 0.53 mL 2.66 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

He et al (2015) Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat.Commun. 7 13122 PMID: 7959342

Zhuo et al (2015) Ailanthone inhibits Huh7 cancer cell growth via cell cycle arrest and apoptosis in vitro and in vivo. Sci.Rep. 5 16185 PMID: 6525771


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Keywords: Ailanthone, supplier, Inhibitors, Inhibits, AR, Androgen, Receptor, p23, HSP90, Ubiquitin, Protease, System, UPS, apoptosis, prostate, cancer, Huh7, CRPC, castration-resistant, prostate, cancer, Androgen, Receptor, Androgen, Receptor, Tocris Bioscience

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