ADU-S100 disodium salt

Pricing Availability   Qty
Description: STING agonist
Chemical Name: [P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium
Purity: ≥95% (HPLC)
Datasheet
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Biological Activity for ADU-S100 disodium salt

ADU-S100 disodium salt is a STING agonist. It induces CD8+ T-cell mediated antitumor immunity in a rat esophageal adenocarcinoma model. In mouse tumor models, the compound induces tumor regression and a potent antitumor immune response. ADU-S100 disodium salt induces phosphorylation of TBK1 and IRF3 in murine bone marrow macrophages.

Technical Data for ADU-S100 disodium salt

M. Wt 734.5
Formula C20H22N10Na2O10P2S2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1638750-95-4
PubChem ID 135390762
InChI Key GDWOOOCBNOMMTL-ITQXCAEYSA-L
Smiles O[C@H]1[C@]2([H])[C@H](N3C4=NC=NC(N)=C4N=C3)O[C@]1([H])CO[P@@]([S-])(O[C@]5([H])[C@@](O[C@@H](N6C7=NC=NC(N)=C7N=C6)[C@@H]5O)([H])CO[P@@]([S-])(O2)=O)=O.[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ADU-S100 disodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.67 5

Preparing Stock Solutions for ADU-S100 disodium salt

The following data is based on the product molecular weight 734.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 27.23 mL 136.15 mL 272.29 mL
0.25 mM 5.45 mL 27.23 mL 54.46 mL
0.5 mM 2.72 mL 13.61 mL 27.23 mL
2.5 mM 0.54 mL 2.72 mL 5.45 mL

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Product Datasheets for ADU-S100 disodium salt

References for ADU-S100 disodium salt

References are publications that support the biological activity of the product.

Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018 PMID: 25959818

Zaidi et al (2021) Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model. Oncotarget 12 292 PMID: 33659041


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Keywords: ADU-S100 disodium salt, ADU-S100 disodium salt supplier, STING, agonist, agonism, apoptosis, signaling, cancer, in, vivo, T-cells, immunity, antitumor, CD8+, STING-Dependent, Signaling, 7706, Tocris Bioscience

Citations for ADU-S100 disodium salt

Citations are publications that use Tocris products.

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