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Cat.No. 2784 - Acipimox | C6H6N2O3 | CAS No. 51037-30-0
Description: Antilipolytic agent
Chemical Name: 5-Methyl-4-oxide-2-pyrazinecarboxylic acid
Purity: ≥99% (HPLC)

Biological Activity

Antilipolytic agent; lowers plasma free fatty acid (FFA), triglyceride (TG), glucose and insulin levels and increases leptin levels.

Technical Data

M. Wt 154.12
Formula C6H6N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51037-30-0
PubChem ID 5310993
Smiles CC1=CN=C(C(O)=O)C=[N+]1[O-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 15.41 100
DMSO 15.41 100

Preparing Stock Solutions

The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.49 mL 32.44 mL 64.88 mL
5 mM 1.3 mL 6.49 mL 12.98 mL
10 mM 0.65 mL 3.24 mL 6.49 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

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References are publications that support the biological activity of the product.

Wang-Fisher et al (2002) Acipimox stimulates leptin production from isolated rat adipocytes. J.Endocrinol. 174 267 PMID: 12176665

Lovisolo et al (1981) Pharmacological proflie of a new antilipolytic agent: 5-methyl-pyrazine-2-carboxylic acid 4-oxide (acipimox) II - Antilipolytic and blood lipid lowering activitiy Pharmacol.Res.Comms. 13 163

Christie et al (1996) Mechanism of anti-lipolytic action of acipimox in isolated rat adipocytes. Diabetol. 39 45

If you know of a relevant reference for Acipimox, please let us know.

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Keywords: Acipimox, Acipimox supplier, Antilipolytic, agent, Lipid, Metabolism, Other, 2784, Tocris Bioscience

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