Acipimox

Pricing Availability Delivery Time Qty
Cat.No. 2784 - Acipimox | C6H6N2O3 | CAS No. 51037-30-0
Description: Antilipolytic agent
Chemical Name: 5-Methyl-4-oxide-2-pyrazinecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antilipolytic agent; lowers plasma free fatty acid (FFA), triglyceride (TG), glucose and insulin levels and increases leptin levels.

Compound Libraries

Acipimox is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 154.12
Formula C6H6N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 51037-30-0
PubChem ID 5310993
InChI Key DJQOOSBJCLSSEY-UHFFFAOYSA-N
Smiles CC1=CN=C(C(O)=O)C=[N+]1[O-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.41 100
water 15.41 100

Preparing Stock Solutions

The following data is based on the product molecular weight 154.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.49 mL 32.44 mL 64.88 mL
5 mM 1.3 mL 6.49 mL 12.98 mL
10 mM 0.65 mL 3.24 mL 6.49 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wang-Fisher et al (2002) Acipimox stimulates leptin production from isolated rat adipocytes. J.Endocrinol. 174 267 PMID: 12176665

Lovisolo et al (1981) Pharmacological proflie of a new antilipolytic agent: 5-methyl-pyrazine-2-carboxylic acid 4-oxide (acipimox) II - Antilipolytic and blood lipid lowering activitiy Pharmacol.Res.Comms. 13 163 PMID:

Christie et al (1996) Mechanism of anti-lipolytic action of acipimox in isolated rat adipocytes. Diabetol. 39 45 PMID:


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Keywords: Acipimox, supplier, Antilipolytic, agent, Lipid, Metabolism, Other, Lipid, Metabolism, Other, Lipid, Metabolism, Tocris Bioscience

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