NMDA receptor partial agonist, acting at the glycine site of NR1.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 115.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||8.69 mL||43.43 mL||86.86 mL|
|5 mM||1.74 mL||8.69 mL||17.37 mL|
|10 mM||0.87 mL||4.34 mL||8.69 mL|
|50 mM||0.17 mL||0.87 mL||1.74 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hood et al (1989) 1-Aminocyclobutane-1-carboxylic acid (ACBC): a specific antagonist of the NMDA receptor coupled glycine receptor. Eur.J.Pharmacol. 161 281 PMID: 2542048
Inanobe et al (2005) Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron 47 71 PMID: 15996549
Rao et al (1990) Neuropharmacological characterization of 1-aminocyclopropane-1-carboxylate and 1-aminocyclobutane-1-carboxylate, ligands of the N-methyl-D-aspartate-associated glycine receptor. Neuropharmacology 29 305 PMID: 2158004
If you know of a relevant reference for ACBC, please let us know.
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Keywords: NMDA antagonists glycine site Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors
Citations for ACBC
Citations are publications that use Tocris products.
Currently there are no citations for ACBC. Do you know of a great paper that uses ACBC from Tocris? If so please let us know.
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