AC 55541

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Cat.No. 3369 - AC 55541 | C25H20BrN5O3 | CAS No. 916170-19-9
Description: Potent and selective PAR2 agonist
Chemical Name: (2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide
Purity: ≥97% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (3)

Biological Activity for AC 55541

AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro (pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

Technical Data for AC 55541

M. Wt 518.36
Formula C25H20BrN5O3
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 916170-19-9
PubChem ID 9589606
InChI Key UCUHFWIFSHROPY-RWPZCVJISA-N
Smiles O=C2C1=CC=CC=C1C(C(NC(C3=CC=CC=C3)=O)C(N/N=C(C)/C4=CC=CC(Br)=C4)=O)=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AC 55541

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.92 50

Preparing Stock Solutions for AC 55541

The following data is based on the product molecular weight 518.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.86 mL 19.29 mL 38.58 mL
2.5 mM 0.77 mL 3.86 mL 7.72 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
25 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets for AC 55541

Certificate of Analysis / Product Datasheet
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References for AC 55541

References are publications that support the biological activity of the product.

Seitzberg et al (2008) Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 51 5490 PMID: 18720984

Gardell et al (2008) Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 327 799 PMID: 18768780


If you know of a relevant reference for AC 55541, please let us know.

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Keywords: AC 55541, AC 55541 supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, AC55541, 3369, Tocris Bioscience

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Literature in this Area

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