AA 2414

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Cat.No. 3025 - AA 2414 | C22H26O4 | CAS No. 112665-43-7
Description: Thromboxane A2 (TP) receptor antagonist
Alternative Names: Seratrodast
Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (6)

Biological Activity

Thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.

Technical Data

M. Wt 354.44
Formula C22H26O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 112665-43-7
PubChem ID 2449
InChI Key ZBVKEHDGYSLCCC-UHFFFAOYSA-N
Smiles O=C1C(C)=C(C)C(C(C(C2=CC=CC=C2)CCCCCC(O)=O)=C1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 26.58 75
DMSO 35.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 354.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References

References are publications that support the biological activity of the product.

Ashida et al (1989) A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38 91 PMID: 2748922

Kurokawa et al (1994) Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414. Biol.Pharm.Bull. 17 383 PMID: 8019502

Cui et al (2007) Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. Eur.J.Pharmacol. 576 99 PMID: 17706964


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Keywords: AA 2414, AA 2414 supplier, Thromboxane, A2, TP, receptors, antagonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, AA2414, Seratrodast, Receptors, 3025, Tocris Bioscience

1 Citation for AA 2414

Citations are publications that use Tocris products. Selected citations for AA 2414 include:

Hennenberg et al (2013) The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle. Am J Physiol Renal Physiol 305 F1383 PMID: 24049147


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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