AA 2414

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Cat.No. 3025 - AA 2414 | C22H26O4 | CAS No. 112665-43-7
Description: Thromboxane A2 (TP) receptor antagonist
Alternative Names: Seratrodast
Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.

Technical Data

M. Wt 354.44
Formula C22H26O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 112665-43-7
PubChem ID 2449
InChI Key ZBVKEHDGYSLCCC-UHFFFAOYSA-N
Smiles O=C1C(C)=C(C)C(C(C(C2=CC=CC=C2)CCCCCC(O)=O)=C1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 26.58 75
DMSO 35.44 100
ethanol 17.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 354.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.21 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ashida et al (1989) A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38 91 PMID: 2748922

Kurokawa et al (1994) Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414. Biol.Pharm.Bull. 17 383 PMID: 8019502

Cui et al (2007) Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. Eur.J.Pharmacol. 576 99 PMID: 17706964


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Keywords: AA 2414, supplier, Thromboxane, A2, TP, receptors, antagonists, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, AA2414, Seratrodast, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience

Citations for AA 2414

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