α-helical CRF 9-41

Pricing Availability   Qty
Cat.No. 1184 - alpha-helical CRF 9-41 | Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2 | CAS No. 90880-23-2
Description: CRF antagonist
Alternative Names: α-helical-Corticotropin-Releasing Factor 9-41
Datasheet
Citations (2)
Reviews (1)
Literature (3)

Biological Activity

Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).

Licensing Information

Sold with the permission of the SALK Institute

Technical Data

M. Wt 3827
Formula C166H274N46O53S2
Sequence DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA

(Modifications: Ala-33 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 90880-23-2
PubChem ID 44593730
InChI Key PNGVJHODDQMQKT-GVKLFNHCSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 0.1% TFA

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kask et al (1997) Alpha-helical(9-41) revents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226. NeuroReport 8 3645 PMID: 9427342

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312 PMID: 10816663

Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41). Neuropsychopharmacology 2 285 PMID: 2610824


If you know of a relevant reference for α-helical CRF 9-41, please let us know.

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Keywords: alpha-helical CRF 9-41, alpha-helical CRF 9-41 supplier, CRF, receptor, antagonists, Corticotropin-Releasing, Factor, Non-Selective, Receptors, α-helical, alpha-helical, 9-41, a-helical, CRF9-41, a-helical-Corticotropin-Releasing, Factor9-41, Non-selective, 1184, Tocris Bioscience

2 Citations for α-helical CRF 9-41

Citations are publications that use Tocris products. Selected citations for α-helical CRF 9-41 include:

Wang et al (2014) Involvement of CRH and hCG in the induction of aromatase by cortisol in human placental syncytiotrophoblasts. Placenta 35 30 PMID: 24239159

Jia et al (2013) Role of nesfatin-1 in a rat model of visceral hypersensitivity. J Immunol 19 3487 PMID: 23801843


Do you know of a great paper that uses α-helical CRF 9-41 from Tocris? Please let us know.

Reviews for α-helical CRF 9-41

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cell treatment.
By Anonymous on 05/31/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: placental cytotrophoblast

cell treatment


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