α-helical CRF 9-41

Pricing Availability Delivery Time Qty
Cat.No. 1184 - alpha-helical CRF 9-41 | Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2 | CAS No. 90880-23-2
Description: CRF receptor antagonist
Alternative Names: α-helical-Corticotropin-Releasing Factor 9-41
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).

Licensing Information

Sold with the permission of the SALK Institute

Technical Data

M. Wt 3827
Formula C166H274N46O53S2
Sequence DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA

(Modifications: Ala-33 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 90880-23-2
PubChem ID 44593730
InChI Key PNGVJHODDQMQKT-GVKLFNHCSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 0.1% TFA

Preparing Stock Solutions

The following data is based on the product molecular weight 3827. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.26 mL 1.31 mL 2.61 mL
5 mM 0.05 mL 0.26 mL 0.52 mL
10 mM 0.03 mL 0.13 mL 0.26 mL
50 mM 0.01 mL 0.03 mL 0.05 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kask et al (1997) Alpha-helical(9-41) revents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226. NeuroReport 8 3645 PMID: 9427342

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312 PMID: 10816663

Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41). Neuropsychopharmacology 2 285 PMID: 2610824


If you know of a relevant reference for α-helical CRF 9-41, please let us know.

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1 Citation for α-helical CRF 9-41

Citations are publications that use Tocris products. Selected citations for α-helical CRF 9-41 include:

Jia et al (2013) Role of nesfatin-1 in a rat model of visceral hypersensitivity. J Immunol 19 3487 PMID: 23801843


Do you know of a great paper that uses α-helical CRF 9-41 from Tocris? If so please let us know.

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