A 410099.1 amide-PEG4-amine

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Cat.No. 7220 - A 410099.1 amide-PEG4-amine | C42H68N6O10 | CAS No. 2446474-10-6
Description: IAP ligand with PEG linker and terminal amine for onward chemistry
Chemical Name: tert-Butyl ((S)-1-(((S)-2-((2S,4S)-4-(14-amino-3,6,9,12-tetraoxatetradecanamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews

Biological Activity

Functionalized IAP ligand for PROTAC® research and development; incorporates an IAP ligand plus an amide-PEG4 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M. Wt 817.02
Formula C42H68N6O10
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2446474-10-6
InChI Key CDDABGWUXFFTGQ-MLSLTINKSA-N
Smiles CN([C@H](C(N[C@H](C(N1C[C@@H](NC(COCCOCCOCCOCCN)=O)C[C@H]1C(N[C@@H]2CCCC3=CC=CC=C23)=O)=O)C4CCCCC4)=O)C)C(OC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Tinworth et al (2019) PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Biol.Chem. 14 342 PMID: 30807093


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