8-M-PDOT

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Cat.No. 1035 - 8-M-PDOT | C14H19NO2 | CAS No. 134865-70-6
Description: Melatonin agonist
Chemical Name: 8-Methoxy-2-propionamidotetralin
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Melatonin receptor agonist, 20-fold selective for the MT2 (vs MT1) subtype. At human recombinant MT1 and MT2 receptors, displays pKi values of 8.23 and 8.95 respectively.

Technical Data

M. Wt 233.31
Formula C14H19NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 134865-70-6
PubChem ID 5170952
InChI Key RVIGBTUDFAGRTQ-UHFFFAOYSA-N
Smiles CCC(=O)NC1CCC2=C(C1)C(OC)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 50
DMSO 100

Preparing Stock Solutions

The following data is based on the product molecular weight 233.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.29 mL 21.43 mL 42.86 mL
5 mM 0.86 mL 4.29 mL 8.57 mL
10 mM 0.43 mL 2.14 mL 4.29 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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References

References are publications that support the biological activity of the product.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877 PMID: 10696085

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID: 9089668

Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083


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Keywords: 8-M-PDOT, 8-M-PDOT supplier, Melatonin, agonists, Receptors, MT, 8MPDOT, (MT), 1035, Tocris Bioscience

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