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Potent and selective DDR1 inhibitor (IC50 = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC50 values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 546.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.83 mL||9.15 mL||18.3 mL|
|5 mM||0.37 mL||1.83 mL||3.66 mL|
|10 mM||0.18 mL||0.91 mL||1.83 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References are publications that support the biological activity of the product.
Gao et al (2013) Discovery and optimization of 3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J.Med.Chem. 56 3281 PMID: 23521020
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Keywords: 7rh, 7rh supplier, Discoidin, domain, receptors, 1, inhibitors, inhibits, potent, selective, DDR1, orally, bioavailable, Other, RTKs, 5860, Tocris Bioscience
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