Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent and selective DDR1 inhibitor; orally bioavailable
Chemical Name: 4-Ethyl-N-[3-[(4-methyl-1-piperazinyl)methyl]-5-(trifluoromethyl)phenyl]-3-(2-pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
Purity: ≥98% (HPLC)

Biological Activity for 7rh

7rh is a potent and selective DDR1 inhibitor (IC50 = 6.8 nM). Exhibits selectivity for DDR1 over DDR2, Bcr-Abl and c-Kit (IC50 values are 101.4 and 355 nM and > 10 μM, respectively) and a range of other kinases. Inhibits proliferation of cancer cell lines expressing high levels of DDR1 in vitro and suppresses cancer cell invasion, adhesion and tumorigenicity. Orally bioavailable.

Technical Data for 7rh

M. Wt 546.59
Formula C30H29F3N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1429617-90-2
PubChem ID 71550931
Smiles O=C(NC1=CC(CN2CCN(C)CC2)=CC(C(F)(F)F)=C1)C3=CC(C#CC(C=N4)=CN5C4=CC=N5)=C(CC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 7rh

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 54.66 100

Preparing Stock Solutions for 7rh

The following data is based on the product molecular weight 546.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.15 mL 18.3 mL
5 mM 0.37 mL 1.83 mL 3.66 mL
10 mM 0.18 mL 0.91 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for 7rh

Certificate of Analysis / Product Datasheet
Select another batch:

References for 7rh

References are publications that support the biological activity of the product.

Gao et al (2013) Discovery and optimization of 3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J.Med.Chem. 56 3281 PMID: 23521020

If you know of a relevant reference for 7rh, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other RTKs Inhibitors

Keywords: 7rh, 7rh supplier, Discoidin, domain, receptors, 1, inhibitors, inhibits, potent, selective, DDR1, orally, bioavailable, Other, RTKs, 5860, Tocris Bioscience

Citations for 7rh

Citations are publications that use Tocris products.

Currently there are no citations for 7rh. Do you know of a great paper that uses 7rh from Tocris? Please let us know.

Reviews for 7rh

There are currently no reviews for this product. Be the first to review 7rh and earn rewards!

Have you used 7rh?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review