7α,25-Dihydroxycholesterol
Biological Activity
Highly potent GPR183 (EBI2) agonist (EC50 = 140 pM) and putative natural ligand for GPR183. Regulates migration of B and T cells expressing GPR183 in vivo. Desensitizes B cells and reduces their movement to splenic follicles.
Technical Data
| M. Wt | 418.65 |
| Formula | C27H46O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 64907-22-8 |
| PubChem ID | 11954197 |
| InChI Key | BQMSKLCEWBSPPY-IKVTXIKFSA-N |
| Smiles | O[C@H](C1)CC[C@@]2(C)C1=C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)(O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.19 | 10 with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 418.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.89 mL | 119.43 mL | 238.86 mL |
| 0.5 mM | 4.78 mL | 23.89 mL | 47.77 mL |
| 1 mM | 2.39 mL | 11.94 mL | 23.89 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Liu et al (2011) Oxysterols direct B-cell migration through EBI2. Nature. 475 519 PMID: 21796211
Hannedouche et al (2011) Oxysterols direct immune cell migration via EBI2. Nature. 475 524 PMID: 21796212
If you know of a relevant reference for 7α,25-Dihydroxycholesterol, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 7alpha,25-Dihydroxycholesterol, 7alpha,25-Dihydroxycholesterol supplier, 7a,25-Dihydroxycholesterol, GPR183, EBI2, B, cell, T, migration, densensitizer, active, in, vivo, Epstein, Barr, virus, induced, G, protein, coupled, receptor, 2, infection, spleen, Orphan, 7-TM, Receptors, 6277, Tocris Bioscience
Citations for 7α,25-Dihydroxycholesterol
Citations are publications that use Tocris products.
Currently there are no citations for 7α,25-Dihydroxycholesterol. Do you know of a great paper that uses 7α,25-Dihydroxycholesterol from Tocris? Please let us know.
Reviews for 7α,25-Dihydroxycholesterol
There are currently no reviews for this product. Be the first to review 7α,25-Dihydroxycholesterol and earn rewards!
Have you used 7α,25-Dihydroxycholesterol?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
