Highly potent GPR183 (EBI2) agonist (EC50 = 140 pM) and putative natural ligand for GPR183. Regulates migration of B and T cells expressing GPR183 in vivo. Desensitizes B cells and reduces their movement to splenic follicles.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.19||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 418.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.39 mL||11.94 mL||23.89 mL|
|5 mM||0.48 mL||2.39 mL||4.78 mL|
|10 mM||0.24 mL||1.19 mL||2.39 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Liu et al (2011) Oxysterols direct B-cell migration through EBI2. Nature. 475 519 PMID: 21796211
Hannedouche et al (2011) Oxysterols direct immune cell migration via EBI2. Nature. 475 524 PMID: 21796212
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Keywords: 7alpha,25-Dihydroxycholesterol, 7alpha,25-Dihydroxycholesterol supplier, 7a,25-Dihydroxycholesterol, GPR183, EBI2, B, cell, T, migration, densensitizer, active, in, vivo, Epstein, Barr, virus, induced, G, protein, coupled, receptor, 2, infection, spleen, Orphan, 7-TM, Receptors, 6277, Tocris Bioscience
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