7α,25-Dihydroxycholesterol

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Cat.No. 6277 - 7alpha,25-Dihydroxycholesterol | C27H46O3 | CAS No. 64907-22-8
Description: Highly potent GPR183 (EBI2) agonist
Chemical Name: (3β,7α)-Cholest-5-ene-3,7,25-triol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Highly potent GPR183 (EBI2) agonist (EC50 = 140 pM) and putative natural ligand for GPR183. Regulates migration of B and T cells expressing GPR183 in vivo. Desensitizes B cells and reduces their movement to splenic follicles.

Technical Data

M. Wt 418.65
Formula C27H46O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 64907-22-8
PubChem ID 11954197
InChI Key BQMSKLCEWBSPPY-IKVTXIKFSA-N
Smiles O[C@H](C1)CC[C@@]2(C)C1=C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)(O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.19 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 418.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.94 mL 23.89 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
10 mM 0.24 mL 1.19 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Liu et al (2011) Oxysterols direct B-cell migration through EBI2. Nature. 475 519 PMID: 21796211

Hannedouche et al (2011) Oxysterols direct immune cell migration via EBI2. Nature. 475 524 PMID: 21796212


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Citations for 7α,25-Dihydroxycholesterol

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