6-Chloromelatonin

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Cat.No. 0443 - 6-Chloromelatonin | C13H15ClN2O2 | CAS No. 63762-74-3
Description: Melatonin agonist
Chemical Name: N-[2-(6-Chloro-5-methoxyindol-3-yl)ethyl]acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent melatonin agonist (pKi values are 9.10 and 9.77 for human recombinant MT1 and MT2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.

Compound Libraries

6-Chloromelatonin is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 266.73
Formula C13H15ClN2O2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 63762-74-3
PubChem ID 1858
InChI Key LUINDDOUWHRIPW-UHFFFAOYSA-N
Smiles COC1=C(Cl)C=C2NC=C(CCNC(C)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 266.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.75 mL 37.49 mL
5 mM 0.75 mL 3.75 mL 7.5 mL
10 mM 0.37 mL 1.87 mL 3.75 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877 PMID: 10696085

Dubocovich (1988) Luzindole (NO 774): A novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902 PMID: 2843633

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083

Duncan et al (1988) 2-[125I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology 122 1825 PMID: 2834175


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Keywords: Melatonin agonists MT Receptors Melatonin (MT) Receptors

Citations for 6-Chloromelatonin

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GPCR

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Pathways for 6-Chloromelatonin

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