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Potent oxoeicosanoid (OXE) receptor agonist (EC50 = 0.33 nM). Chemoattractant for both neutrophils and eosinophils and induces transendothelial migration of eosinophils.
|Storage||Store at -80°C|
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Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Powell et al (1994) Effects of phorbol myristate acetate on the synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human polymorphonuclear leukocytes. Biochemistry 33 3927 PMID: 8142396
Jones et al (2003) Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Mol.Pharmacol. 63 471 PMID: 12606753
Patel et al (2008) Structural requirements for activation of the 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor: identification of a mead acid metabolite with potent agonist activity. J.Pharmacol.Exp.Ther. 325 698 PMID: 18292294
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Keywords: 5-oxo-ETE, 5-oxo-ETE supplier, Oxoeicosanoid, receptor, agonists, Receptors, leukotrienes, eicosanoids, 5-KETE, Leukotriene, and, Related, 1796, Tocris Bioscience
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