5-Oxo-ETE

Discontinued Product

Unfortunately 5-Oxo-ETE (Cat. No. 1796) has been withdrawn from sale for commercial reasons.
Cat.No. 1796 - 5-oxo-ETE | C20H30O3 | CAS No. 106154-18-1
Description: Oxoeicosanoid receptor agonist
Alternative Names: 5-KETE
Chemical Name: 5-Oxo-(6E,8Z,11Z,14Z)-6,8,11,14-eicosatetraenoic acid
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent oxoeicosanoid (OXE) receptor agonist (EC50 = 0.33 nM). Chemoattractant for both neutrophils and eosinophils and induces transendothelial migration of eosinophils.

Technical Data

M. Wt 318.46
Formula C20H30O3
Storage Store at -80°C
Purity ≥95% (HPLC)
CAS Number 106154-18-1
Smiles CCCCC\C=C/C\C=C/C\C=C/C=C/C(CCCC(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 318.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.7 mL 31.4 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Powell et al (1994) Effects of phorbol myristate acetate on the synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human polymorphonuclear leukocytes. Biochemistry 33 3927 PMID: 8142396

Jones et al (2003) Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. Mol.Pharmacol. 63 471 PMID: 12606753

Patel et al (2008) Structural requirements for activation of the 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor: identification of a mead acid metabolite with potent agonist activity. J.Pharmacol.Exp.Ther. 325 698 PMID: 18292294

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Keywords: 5-oxo-ETE, supplier, Oxoeicosanoid, receptor, agonists, Receptors, leukotrienes, eicosanoids, 5-KETE, Leukotriene, and, Related, Receptors, Leukotriene, and, Related, Receptors, Tocris Bioscience

Citations for 5-Oxo-ETE

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Currently there are no citations for 5-Oxo-ETE.

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