4-[N-(4-Chlorophenyl)carbamoyloxy]-4-pent-2-ynyl-trimethyl ammonium iodide
Discontinued ProductUnfortunately 4-[N-(4-Chlorophenyl)carbamoyloxy]-4-pent-2-ynyl-trimethyl ammonium iodide (Cat. No. 0466) has been withdrawn from sale for commercial reasons.
A partial agonist with 16 times the power of the analogue McN-A-343 in increasing arterial blood pressure and 18 times the affinity of the latter for ganglionic M1 receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 422.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.37 mL||11.83 mL||23.66 mL|
|5 mM||0.47 mL||2.37 mL||4.73 mL|
|10 mM||0.24 mL||1.18 mL||2.37 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
References are publications that support the products' biological activity.
Nilsson et al (1992) Amide, urea and carbamate analogues of the muscarinic agent [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride. J.Med.Chem. 35 2787 PMID: 1379640
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Keywords: 4-[N-(4-Chlorophenyl)carbamoyloxy]-4-pent-2-ynyl-trimethylammonium iodide, supplier, Non-selective, Muscarinics, Non-selective, Muscarinics, Tocris Bioscience
Citations for 4-[N-(4-Chlorophenyl)carbamoyloxy]-4-pent-2-ynyl-trimethyl ammonium iodide
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.