4-DAMP

Pricing Availability Delivery Time Qty
Cat.No. 0482 - 4-DAMP | C21H26INO2 | CAS No. 1952-15-4
Description: Muscarinic M3 antagonist
Chemical Name: 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
Purity: ≥99% (HPLC)
Datasheet
Citations (11)
Literature

Biological Activity

Antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors.

Technical Data

M. Wt 451.33
Formula C21H26INO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1952-15-4
PubChem ID 3014059
InChI Key WWJHRSCUAQPFQO-UHFFFAOYSA-M
Smiles [I-].C[N+]1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.28 25

Preparing Stock Solutions

The following data is based on the product molecular weight 451.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.08 mL 22.16 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Barlow and Shepherd (1986) A further search for selective antagonists at M2- muscarinic receptors. Br.J.Pharmacol. 89 837 PMID: 3814912

Michel et al (1989) Direct labelling of rat M3-muscarinic receptors by [3H]4-DAMP. Eur.J.Pharmacol. 166 459 PMID: 2806372


If you know of a relevant reference for 4-DAMP, please let us know.

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Keywords: Muscarinic M3 antagonists Receptors Acetylcholine Ach M3 Receptors

11 Citations for 4-DAMP

Citations are publications that use Tocris products. Selected citations for 4-DAMP include:

Fonseca et al (2015) Diadenosine tetraphosphate contributes to carbachol-induced tear secretion. Purinergic Signal 11 87 PMID: 25398705

Wallace et al (2015) Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine. Microvasc Res 3 PMID: 26359240

Nedvetsky et al (2014) Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell 30 449 PMID: 25158854

Placeres-Uray et al (2014) M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation. World Allergy Organ J 6 22 PMID: 24377382

Pacini et al (2014) M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther 15 1489 PMID: 25482946

Mans et al (2014) An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol 112 2388 PMID: 25143547

Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364 PMID: 24078773

Hodges et al (2012) Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion. Exp Eye Res 103 99 PMID: 22975404

Kajiya et al (2012) Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. J Neurosci 82 115 PMID: 22511543

Kitazawa et al (2009) M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. Mol Pharmacol 330 487 PMID: 19429792

Clancy et al (2007) Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. Physiol Rep 27 6388 PMID: 17567799


Do you know of a great paper that uses 4-DAMP from Tocris? If so please let us know.

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Pathways for 4-DAMP

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