4,4-Pentamethylenepiperidine hydrochloride

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Cat.No. 3692 - 4,4-Pentamethylenepiperidine hydrochloride | C10H19N.HCl | CAS No. 1125-01-5
Description: M2 proton channel blocker
Chemical Name: 3-Azaspiro[5.5]undecane hydrochloride

Biological Activity

M2 proton channel blocker (IC50 = 0.92 μM). Inhibits influenza virus M2 protein (AM2).

Technical Data

M. Wt 189.73
Formula C10H19N.HCl
Storage Desiccate at RT
CAS Number 1125-01-5
PubChem ID 22252831

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.97 100
ethanol 18.97 100
water 18.97 100

Preparing Stock Solutions

The following data is based on the product molecular weight 189.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.27 mL 26.35 mL 52.71 mL
5 mM 1.05 mL 5.27 mL 10.54 mL
10 mM 0.53 mL 2.64 mL 5.27 mL
50 mM 0.11 mL 0.53 mL 1.05 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Wang et al (2009) Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from Influenza A Virus. J.Am.Chem.Soc. 131 8066 PMID: 19469531

If you know of a relevant reference for 4,4-Pentamethylenepiperidine hydrochloride, please let us know.

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Keywords: M2 proton channels blockers influenza virus protein AM2 modulators Other Channel Modulators

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