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M2 proton channel blocker (IC50 = 0.92 μM). Inhibits influenza virus M2 protein (AM2).
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 189.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.27 mL||26.35 mL||52.71 mL|
|5 mM||1.05 mL||5.27 mL||10.54 mL|
|10 mM||0.53 mL||2.64 mL||5.27 mL|
|50 mM||0.11 mL||0.53 mL||1.05 mL|
References are publications that support the biological activity of the product.
Wang et al (2009) Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from Influenza A Virus. J.Am.Chem.Soc. 131 8066 PMID: 19469531
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Keywords: 4,4-Pentamethylenepiperidine hydrochloride, 4,4-Pentamethylenepiperidine hydrochloride supplier, M2, proton, channels, blockers, influenza, virus, protein, AM2, modulators, Other, Channel, Modulators, 3692, Tocris Bioscience
Citations for 4,4-Pentamethylenepiperidine hydrochloride
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Literature in this Area
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