4,4-Pentamethylenepiperidine hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3692 - 4,4-Pentamethylenepiperidine hydrochloride | C10H19N.HCl | CAS No. 1125-01-5
Description: M2 proton channel blocker
Chemical Name: 3-Azaspiro[5.5]undecane hydrochloride
Datasheet
Citations
Literature

Biological Activity

M2 proton channel blocker (IC50 = 0.92 μM). Inhibits influenza virus M2 protein (AM2).

Technical Data

M. Wt 189.73
Formula C10H19N.HCl
Storage Desiccate at RT
CAS Number 1125-01-5
PubChem ID 22252831
InChI Key XDRWSBJRLMRJKA-UHFFFAOYSA-N
Smiles C1CCCCC21CCNCC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.97 100
ethanol 18.97 100
water 18.97 100

Preparing Stock Solutions

The following data is based on the product molecular weight 189.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.27 mL 26.35 mL 52.71 mL
5 mM 1.05 mL 5.27 mL 10.54 mL
10 mM 0.53 mL 2.64 mL 5.27 mL
50 mM 0.11 mL 0.53 mL 1.05 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wang et al (2009) Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from Influenza A Virus. J.Am.Chem.Soc. 131 8066 PMID: 19469531


If you know of a relevant reference for 4,4-Pentamethylenepiperidine hydrochloride, please let us know.

View Related Products by Target

Keywords: M2 proton channels blockers influenza virus protein AM2 modulators Other Channel Modulators

Citations for 4,4-Pentamethylenepiperidine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for 4,4-Pentamethylenepiperidine hydrochloride. Do you know of a great paper that uses 4,4-Pentamethylenepiperidine hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for 4,4-Pentamethylenepiperidine hydrochloride

Protocols

TODO: Add Protocols