4,4-Pentamethylenepiperidine hydrochloride

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Cat.No. 3692 - 4,4-Pentamethylenepiperidine hydrochloride | C10H19N.HCl | CAS No. 1125-01-5
Description: M2 proton channel blocker
Chemical Name: 3-Azaspiro[5.5]undecane hydrochloride
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

M2 proton channel blocker (IC50 = 0.92 μM). Inhibits influenza virus M2 protein (AM2).

Technical Data

M. Wt 189.73
Formula C10H19N.HCl
Storage Desiccate at RT
CAS Number 1125-01-5
PubChem ID 22252831
InChI Key XDRWSBJRLMRJKA-UHFFFAOYSA-N
Smiles C1CCCCC21CCNCC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.97 100
DMSO 18.97 100

Preparing Stock Solutions

The following data is based on the product molecular weight 189.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.27 mL 26.35 mL 52.71 mL
5 mM 1.05 mL 5.27 mL 10.54 mL
10 mM 0.53 mL 2.64 mL 5.27 mL
50 mM 0.11 mL 0.53 mL 1.05 mL

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References

References are publications that support the biological activity of the product.

Wang et al (2009) Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from Influenza A Virus. J.Am.Chem.Soc. 131 8066 PMID: 19469531


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Citations for 4,4-Pentamethylenepiperidine hydrochloride

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