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3',3'-cGAMP sodium salt

Cat. No. 5946 Submit a Review Datasheet / COA / SDS
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Description: STING agonist
Chemical Name: 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
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Citations
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Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 3',3'-cGAMP sodium salt

3',3'-cGAMP sodium salt is a STING agonist. Reduces B cell proliferation and induces apoptosis of malignant B cells in vitro. Suppresses 5TGM1 multiple myeloma xenograft growth in immunodeficient mice, and induces leukemic regression in Eμ-TCL1 mice.

This product is sold in units of 359μg, equivalent to 0.5μmol.

Technical Data for 3',3'-cGAMP sodium salt

M. Wt 718.37
Formula C20H22N10Na2O13P2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2407516-83-8
PubChem ID 121513907
InChI Key MFPHQIYDBUVTRL-DQNSRKNCSA-L
Smiles [H][C@@]12COP(O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O[C@@]1([H])[C@@H](O)[C@@H](O2)N4C=NC5=C4N=C(NC5=O)N)(O[Na])=O)N6C=NC7=C(N)N=CN=C67)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 3',3'-cGAMP sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.18 10

Preparing Stock Solutions for 3',3'-cGAMP sodium salt

The following data is based on the product molecular weight 718.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.92 mL 69.6 mL 139.2 mL
0.5 mM 2.78 mL 13.92 mL 27.84 mL
1 mM 1.39 mL 6.96 mL 13.92 mL
5 mM 0.28 mL 1.39 mL 2.78 mL

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Product Datasheets for 3',3'-cGAMP sodium salt

Certificate of Analysis / Product Datasheet
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References for 3',3'-cGAMP sodium salt

References are publications that support the biological activity of the product.

Tang et al (2016) Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res. 76 2137 PMID: 26951929

If you know of a relevant reference for 3',3'-cGAMP sodium salt, please let us know.

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Keywords: 3',3'-cGAMP sodium salt, 3',3'-cGAMP sodium salt supplier, STING, agonists, malignant, B-cells, STING-Dependent, Signaling, 5946, Tocris Bioscience

Citations for 3',3'-cGAMP sodium salt

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