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3',3'-cGAMP sodium salt
Biological Activity for 3',3'-cGAMP sodium salt
3',3'-cGAMP sodium salt is a STING agonist. Reduces B cell proliferation and induces apoptosis of malignant B cells in vitro. Suppresses 5TGM1 multiple myeloma xenograft growth in immunodeficient mice, and induces leukemic regression in Eμ-TCL1 mice.
This product is sold in units of 359μg, equivalent to 0.5μmol.
Technical Data for 3',3'-cGAMP sodium salt
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 3',3'-cGAMP sodium salt
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 3',3'-cGAMP sodium salt
The following data is based on the product molecular weight 718.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||13.92 mL||69.6 mL||139.2 mL|
|0.5 mM||2.78 mL||13.92 mL||27.84 mL|
|1 mM||1.39 mL||6.96 mL||13.92 mL|
|5 mM||0.28 mL||1.39 mL||2.78 mL|
Product Datasheets for 3',3'-cGAMP sodium salt
References for 3',3'-cGAMP sodium salt
References are publications that support the biological activity of the product.
Tang et al (2016) Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res. 76 2137 PMID: 26951929
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Keywords: 3',3'-cGAMP sodium salt, 3',3'-cGAMP sodium salt supplier, STING, agonists, malignant, B-cells, STING-Dependent, Signaling, 5946, Tocris Bioscience
Citations for 3',3'-cGAMP sodium salt
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