3',3'-cGAMP sodium salt

Pricing Availability Delivery Time Qty
Cat.No. 5946 - 3',3'-cGAMP sodium salt | C20H22N10Na2O13P2
Description: STING agonist
Chemical Name: 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

STING agonist. Reduces B cell proliferation and induces apoptosis of malignant B cells in vitro. Suppresses 5TGM1 multiple myeloma xenograft growth in immunodeficient mice, and induces leukemic regression in Eμ-TCL1 mice.

This product is sold in units of 359μg, equivalent to 0.5μmol.

Technical Data

M. Wt 718.37
Formula C20H22N10Na2O13P2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513907
InChI Key MFPHQIYDBUVTRL-DQNSRKNCSA-L
Smiles [H][C@@]12COP(O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O[C@@]1([H])[C@@H](O)[C@@H](O2)N4C=NC5=C4N=C(NC5=O)N)(O[Na])=O)N6C=NC7=C(N)N=CN=C67)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.18 10

Preparing Stock Solutions

The following data is based on the product molecular weight 718.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.96 mL 13.92 mL
5 mM 0.28 mL 1.39 mL 2.78 mL
10 mM 0.14 mL 0.7 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tang et al (2016) Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res. 76 2137 PMID: 26951929


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Keywords: 3',3'-cGAMP sodium salt, supplier, STING, agonists, malignant, B-cells, STING-Dependent, Signaling, STING-Dependent, Signaling, Tocris Bioscience

Citations for 3',3'-cGAMP sodium salt

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Literature in this Area

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