3',2'-cGAMP sodium salt

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Description: Induces expression of STING and STING-related genes; antiviral
Chemical Name: 3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for 3',2'-cGAMP sodium salt

3',2'-cGAMP sodium salt is a second messenger in the antiviral immune response in Drosophila melanogaster and in bacteria. 3',2'-cGAMP is selective for Drosophila stimulator of interferon genes (dSTING); induces expression of STING and STING-related genes. After injection of drosophila C virus dsRNA into Drosophila, 3',2'-cGAMP activates STING-dependent antiviral immunity in vivo, reduces viral RNA load and increases survival. In bacteria 3',2'-cGAMP activates DNA degradation of AsCap5 and LlCap5.

Technical Data for 3',2'-cGAMP sodium salt

M. Wt 718.38
Formula C20H22N10Na2O13P2
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key ROQCYAKTZSZNCA-DQNSRKNCSA-L
Smiles O[C@H]1[C@@]2([C@@]([H])(O[C@@]1(COP([O-])(O[C@@]3([C@@]([H])(COP([O-])(O2)=O)O[C@]([H])([C@@H]3O)N4C5=C(N=C4)C(N=C(N)N5)=O)[H])=O)[H])N6C7=NC=NC(N)=C7N=C6)[H].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 3',2'-cGAMP sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.18 10

Preparing Stock Solutions for 3',2'-cGAMP sodium salt

The following data is based on the product molecular weight 718.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.92 mL 69.6 mL 139.2 mL
0.5 mM 2.78 mL 13.92 mL 27.84 mL
1 mM 1.39 mL 6.96 mL 13.92 mL
5 mM 0.28 mL 1.39 mL 2.78 mL

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Product Datasheets for 3',2'-cGAMP sodium salt

References for 3',2'-cGAMP sodium salt

References are publications that support the biological activity of the product.

Slavik et al (2021) cGAS-like receptors sense RNA and control 3',2'-cGAMP signalling in Drosophila. Nature 597 109 PMID: 34261127

Fatma et al (2021) Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger. Nat.Commun. 12 6831 PMID: 34737303


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Citations for 3',2'-cGAMP sodium salt

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