(2R,3S)-Chlorpheg

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Cat.No. 0817 - (2R,3S)-Chlorpheg | C11H12ClNO4 | CAS No. 140924-23-8
Description: Weak NMDA antagonist
Chemical Name: (2R,3S)-β-p-Chlorophenylglutamic acid
Datasheet
Citations
Literature

Biological Activity

A weakly active NMDA receptor antagonist.

Technical Data

M. Wt 257.67
Formula C11H12ClNO4
Storage Store at RT
CAS Number 140924-23-8
PubChem ID 6604761
InChI Key ZHXBCPSYEAQEHB-PSASIEDQSA-N
Smiles N[C@@]([H])([C@@](O)=O)[C@@](CC(O)=O)([H])C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 19.33 75mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 257.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.88 mL 19.4 mL 38.81 mL
5 mM 0.78 mL 3.88 mL 7.76 mL
10 mM 0.39 mL 1.94 mL 3.88 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Chalmers et al (1995) Differential actions of 3-(4-chlorophenyl)glutamic acid stereoisomers and L-trans-pyrrolidine-2,4-dicarboxylic acid upon L-homocysteic acid and L-glutamic acid-induced responses from rat spinal motoneurones. Neuropharmacology 34 1589 PMID: 8788956

Jane et al (1996) Diastereoselective synthesis of all four isomers of 3-(4-chlorophenylglutamic acid: identification of the isomers responsible for the potentiation of L-homocysteic acid-evoked depolarizations in neonatal rat motoneurons. J.Med.Chem. 39 4738 PMID: 8941386


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Keywords: NMDA antagonists Glutamate Receptors N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors

Citations for (2R,3S)-Chlorpheg

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