2-Palmitoylglycerol

Pricing Availability Delivery Time Qty
Cat.No. 2206 - 2-Palmitoylglycerol | C19H38O4 | CAS No. 23470-00-0
Description: Endogenous lipid; enhances activity of 2-arachidonylglycerol (Cat. No. 1298)
Alternative Names: 2-Palm-Gl, 2-PG
Chemical Name: 2-Hydroxy-1-(hydroxymethyl)ethyl hexadecanoic acid ester
Datasheet
Citations
Literature

Biological Activity

Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol (Cat. No. 1298). Does not bind to CB1 or CB2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.

Technical Data

M. Wt 330.51
Formula C19H38O4
Storage Store at -20°C
CAS Number 23470-00-0
PubChem ID 123409
InChI Key BBNYCLAREVXOSG-UHFFFAOYSA-N
Smiles OCC(CO)OC(CCCCCCCCCCCCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.05 100
ethanol 33.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 330.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ben-Shabat et al (1998) An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity. Eur.J.Pharmacol. 353 23 PMID: 9721036

Gallily et al (2000) 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice. Eur.J.Pharmacol. 406 R5 PMID: 11011050

Walker et al (2002) Endocannabinoids and related fatty acid derivatives in pain modulation. Chem.Phys.Lipids 121 159 PMID: 12505698


If you know of a relevant reference for 2-Palmitoylglycerol, please let us know.

View Related Products by Target

Keywords: 2-Palmitoylglycerol, supplier, Endogenous, lipid, enhances, activity, 2-AG, cannabinoid, receptors, fatty, acid, glycerol, ester, 2-arachidonylglycerol, 2-Palm-Gl, 2-PG, Other, Cannabinoids, Tocris Bioscience

Citations for 2-Palmitoylglycerol

Citations are publications that use Tocris products.

Currently there are no citations for 2-Palmitoylglycerol. Do you know of a great paper that uses 2-Palmitoylglycerol from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Pathways for 2-Palmitoylglycerol

Protocols

TODO: Add Protocols