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Cat.No. 2206 - 2-Palmitoylglycerol | C19H38O4 | CAS No. 23470-00-0
Description: Endogenous lipid; enhances activity of 2-arachidonylglycerol (Cat. No. 1298)
Alternative Names: 2-Palm-Gl, 2-PG
Chemical Name: 2-Hydroxy-1-(hydroxymethyl)ethyl hexadecanoic acid ester

Biological Activity

Endogenous fatty acid glycerol ester that enhances activity of 2-arachidonylglycerol (Cat. No. 1298). Does not bind to CB1 or CB2 cannabinoid receptors, but potentiates the apparent binding of 2-AG and increases its ability to inhibit adenylyl cyclase. Enhances in vivo cannabinoid effects of 2-AG following combined administration with 2-linoleoylglycerol.

Technical Data

M. Wt 330.51
Formula C19H38O4
Storage Store at -20°C
CAS Number 23470-00-0
PubChem ID 123409

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 33.05 100
DMSO 33.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 330.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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References are publications that support the biological activity of the product.

Ben-Shabat et al (1998) An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity. Eur.J.Pharmacol. 353 23 PMID: 9721036

Gallily et al (2000) 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-α production in murine macrophages, and in mice. Eur.J.Pharmacol. 406 R5 PMID: 11011050

Walker et al (2002) Endocannabinoids and related fatty acid derivatives in pain modulation. Chem.Phys.Lipids 121 159 PMID: 12505698

If you know of a relevant reference for 2-Palmitoylglycerol, please let us know.

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