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Biological Activity for 2-Iodomelatonin
2-Iodomelatonin is a potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.
Technical Data for 2-Iodomelatonin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 2-Iodomelatonin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 2-Iodomelatonin
The following data is based on the product molecular weight 358.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.79 mL||13.96 mL||27.92 mL|
|5 mM||0.56 mL||2.79 mL||5.58 mL|
|10 mM||0.28 mL||1.4 mL||2.79 mL|
|50 mM||0.06 mL||0.28 mL||0.56 mL|
References for 2-Iodomelatonin
References are publications that support the biological activity of the product.
Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877 PMID: 10696085
Dubocovich and Takahashi (1987) Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 84 3916 PMID: 3035559
Suiciak et al (1991) Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 11 2855 PMID: 1652626
If you know of a relevant reference for 2-Iodomelatonin, please let us know.
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Keywords: 2-Iodomelatonin, 2-Iodomelatonin supplier, High, affinity, melatonin, agonists, MT, Receptors, Melatonin, (MT), 0737, Tocris Bioscience
5 Citations for 2-Iodomelatonin
Citations are publications that use Tocris products. Selected citations for 2-Iodomelatonin include:
Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID: 28473754
Nosjean et al (2000) Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 275 31311 PMID: 10913150
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Stauch et al (2019) Structural basis of ligand recognition at the human MT1 melatonin receptor Nature 569 284 PMID: 31019306
Calamini et al (2008) Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J 413 81 PMID: 18254726
Do you know of a great paper that uses 2-Iodomelatonin from Tocris? Please let us know.
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Literature in this Area
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