Pricing Availability   Qty
Description: High affinity melatonin agonist
Chemical Name: N-[2-(2-Iodo-5-methoxyindol-3-yl)ethyl]acetamide
Purity: ≥98% (HPLC)
Citations (5)

Biological Activity for 2-Iodomelatonin

2-Iodomelatonin is a potent melatonin agonist (pKi values are 10.55 and 9.87 at human recombinant MT1 and MT2 receptors respectively). 2-[125I]-iodomelatonin has been used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

Technical Data for 2-Iodomelatonin

M. Wt 358.18
Formula C13H15IN2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 93515-00-5
PubChem ID 115348
Smiles COC1=CC=C2NC(I)=C(CCNC(C)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 2-Iodomelatonin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.82 100
ethanol 35.82 100

Preparing Stock Solutions for 2-Iodomelatonin

The following data is based on the product molecular weight 358.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.96 mL 27.92 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for 2-Iodomelatonin

Certificate of Analysis / Product Datasheet
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References for 2-Iodomelatonin

References are publications that support the biological activity of the product.

Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877 PMID: 10696085

Dubocovich and Takahashi (1987) Use of 2-[125l]-iodomelatonin to characterize melatonin sites in chicken retina. Proc.Natl.Acad.Sci.U.S.A. 84 3916 PMID: 3035559

Suiciak et al (1991) Quantitative pharmacological analysis of 2-[125l]-iodomelatonin binding sites in discrete areas of the chicken brain. J.Neurosci. 11 2855 PMID: 1652626

If you know of a relevant reference for 2-Iodomelatonin, please let us know.

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Keywords: 2-Iodomelatonin, 2-Iodomelatonin supplier, High, affinity, melatonin, agonists, MT, Receptors, Melatonin, (MT), 0737, Tocris Bioscience

5 Citations for 2-Iodomelatonin

Citations are publications that use Tocris products. Selected citations for 2-Iodomelatonin include:

Calamini et al (2008) Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J 413 81 PMID: 18254726

Stauch et al (2019) Structural basis of ligand recognition at the human MT1 melatonin receptor Nature 569 284 PMID: 31019306

Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888

Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID: 28473754

Nosjean et al (2000) Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 275 31311 PMID: 10913150

Do you know of a great paper that uses 2-Iodomelatonin from Tocris? Please let us know.

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