2-Furoyl-LIGRLO-amide

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Cat.No. 3015 - 2-Furoyl-LIGRLO-amide | 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 | CAS No. 729589-58-6
Description: Potent and selective PAR2 agonist
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.

Technical Data

M. Wt 777.96
Formula C36H63N11O8
Sequence LIGRLX

(Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)

Storage Store at -20°C
CAS Number 729589-58-6
PubChem ID 10395438
InChI Key OSKIRYSKGDEIOG-WTWMNNMUSA-N
Smiles [H]N([C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 777.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.29 mL 6.43 mL 12.85 mL
5 mM 0.26 mL 1.29 mL 2.57 mL
10 mM 0.13 mL 0.64 mL 1.29 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

McGuire et al (2004) 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 309 1124 PMID: 14976230

Alshurafa et al (2004) A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 4 12 PMID: 15265236

Olianas et al (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146 1289 PMID: 17434682


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Keywords: 2-Furoyl-LIGRLO-amide, supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, Protease-Activated, Receptors, Tocris Bioscience

2 Citations for 2-Furoyl-LIGRLO-amide

Citations are publications that use Tocris products. Selected citations for 2-Furoyl-LIGRLO-amide include:

Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Am J Physiol Cell Physiol 34 346 PMID: 24469043

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155


Do you know of a great paper that uses 2-Furoyl-LIGRLO-amide from Tocris? If so please let us know.

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Literature in this Area

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Pathways for 2-Furoyl-LIGRLO-amide

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