Potent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.
(Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 777.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.29 mL||6.43 mL||12.85 mL|
|5 mM||0.26 mL||1.29 mL||2.57 mL|
|10 mM||0.13 mL||0.64 mL||1.29 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
McGuire et al (2004) 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 309 1124 PMID: 14976230
Alshurafa et al (2004) A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 4 12 PMID: 15265236
Olianas et al (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146 1289 PMID: 17434682
If you know of a relevant reference for 2-Furoyl-LIGRLO-amide, please let us know.
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Keywords: 2-Furoyl-LIGRLO-amide, supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, Protease-Activated, Receptors, Tocris Bioscience
2 Citations for 2-Furoyl-LIGRLO-amide
Citations are publications that use Tocris products. Selected citations for 2-Furoyl-LIGRLO-amide include:
Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Am J Physiol Cell Physiol 34 346 PMID: 24469043
Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155
Do you know of a great paper that uses 2-Furoyl-LIGRLO-amide from Tocris? If so please let us know.