Pricing Availability   Qty
Description: Potent and selective PAR2 agonist
Purity: ≥95% (HPLC)
Citations (3)
Reviews (1)
Literature (3)

Biological Activity for 2-Furoyl-LIGRLO-amide

2-Furoyl-LIGRLO-amide is a potent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.

Technical Data for 2-Furoyl-LIGRLO-amide

M. Wt 777.96
Formula C36H63N11O8
Sequence LIGRLX

(Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 729589-58-6
PubChem ID 10395438
Smiles [H]N([C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O)C(=O)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 2-Furoyl-LIGRLO-amide

Solubility Soluble to 1 mg/ml in water

Product Datasheets for 2-Furoyl-LIGRLO-amide

Certificate of Analysis / Product Datasheet
Select another batch:

References for 2-Furoyl-LIGRLO-amide

References are publications that support the biological activity of the product.

McGuire et al (2004) 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 309 1124 PMID: 14976230

Alshurafa et al (2004) A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 4 12 PMID: 15265236

Olianas et al (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146 1289 PMID: 17434682

If you know of a relevant reference for 2-Furoyl-LIGRLO-amide, please let us know.

View Related Products by Product Action

View all Protease-Activated Receptor Agonists

Keywords: 2-Furoyl-LIGRLO-amide, 2-Furoyl-LIGRLO-amide supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, 3015, Tocris Bioscience

3 Citations for 2-Furoyl-LIGRLO-amide

Citations are publications that use Tocris products. Selected citations for 2-Furoyl-LIGRLO-amide include:

Sales et al (2015) Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Am J Physiol Cell Physiol 34 346 PMID: 24469043

Oe et al (2019) Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury. Sci.Rep. 9 2986 PMID: 30814628

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155

Do you know of a great paper that uses 2-Furoyl-LIGRLO-amide from Tocris? Please let us know.

Reviews for 2-Furoyl-LIGRLO-amide

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used 2-Furoyl-LIGRLO-amide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Potent PAR2 Agonist,.
By Anonymous on 09/20/2019
Assay Type: Ex Vivo
Species: Mouse

ex-vivo mouse colonic tissue

Used this compound on an ex-vivo experiment. Tissue: Mouse colon.2F caused massive PAR2 receptor internalization in the colonic mucosa.Very easy to dissolve, great and potent PAR2 Agonist.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.