(1R,1'S,3'R/1R,1'R,3'S)-L-054,264

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Cat.No. 2444 - (1R,1S,3R/1R,1R,3'S)-L-054,264 | C33H41N5O2 | CAS No. 208706-12-1
Description: Potent and selective sst2 agonist
Chemical Name: N-[(1R)-2-[[[(1S*,3R*)-3-(Aminomethyl)cyclohexyl]methyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]spiro[1H-indene-1,4'-piperidine]-1'-carboxamide
Purity: ≥96% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively).

Technical Data

M. Wt 539.71
Formula C33H41N5O2
Storage Store at +4°C
Purity ≥96% (HPLC)
CAS Number 208706-12-1
PubChem ID 9915239
InChI Key DAMXHAMKVXERLM-FVBCXUTKSA-N
Smiles NC[C@H]1CCC[C@@H](CNC([C@H](NC(N4CCC5(C(C=CC=C6)=C6C=C5)CC4)=O)CC2=CNC3=C2C=CC=C3)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.99 50
ethanol 53.97 100

Preparing Stock Solutions

The following data is based on the product molecular weight 539.71. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.26 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Yang et al (1998) Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J.Med.Chem. 41 2175 PMID: 9632348


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Keywords: (1R,1S,3R/1R,1R,3'S)-L-054,264, (1R,1S,3R/1R,1R,3'S)-L-054,264 supplier, Potent, selective, sst2, agonists, sst, Receptors, Somatostatin, (1R,1S,3R/1R,1R,3S)-L-054,264, L054264, 2444, Tocris Bioscience

Citations for (1R,1'S,3'R/1R,1'R,3'S)-L-054,264

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