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Cat.No. 4488 - 1-Deazaadenosine | C11H14N4O4 | CAS No. 14432-09-8
Description: Adenosine deaminase inhibitor
Chemical Name: 3-β-D-Ribofuranosyl-3H-imidazo[4,5-b]pyridin-7-amine
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Inhibitor of adenosine deaminase (Ki = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.

Technical Data

M. Wt 266.25
Formula C11H14N4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 14432-09-8
PubChem ID 159738
Smiles NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.66 25

Preparing Stock Solutions

The following data is based on the product molecular weight 266.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.76 mL 18.78 mL 37.56 mL
5 mM 0.75 mL 3.76 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.76 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Cristalli et al (1993) Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. 28 253 PMID:

Cristalli et al (1987) Improved synthesis and antitumor activity of 1-deazaadenosine. J.Med.Chem. 30 1686 PMID: 3625714

If you know of a relevant reference for 1-Deazaadenosine, please let us know.

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Keywords: 1-Deazaadenosine, supplier, inhibitors, inhibits, adenosine, deaminase, Deaminases, Deaminases, Tocris Bioscience

1 Citation for 1-Deazaadenosine

Citations are publications that use Tocris products. Selected citations for 1-Deazaadenosine include:

Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Anticancer Res 3 e00121 PMID: 26038697

Do you know of a great paper that uses 1-Deazaadenosine from Tocris? If so please let us know.

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
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