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Biological Activity for 1-Deazaadenosine
1-Deazaadenosine is an inhibitor of adenosine deaminase (Ki = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.
Technical Data for 1-Deazaadenosine
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 1-Deazaadenosine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 1-Deazaadenosine
The following data is based on the product molecular weight 266.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||15.02 mL||75.12 mL||150.23 mL|
|1.25 mM||3 mL||15.02 mL||30.05 mL|
|2.5 mM||1.5 mL||7.51 mL||15.02 mL|
|12.5 mM||0.3 mL||1.5 mL||3 mL|
Product Datasheets for 1-Deazaadenosine
References for 1-Deazaadenosine
References are publications that support the biological activity of the product.
Cristalli et al (1993) Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. 28 253
Cristalli et al (1987) Improved synthesis and antitumor activity of 1-deazaadenosine. J.Med.Chem. 30 1686 PMID: 3625714
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Keywords: 1-Deazaadenosine, 1-Deazaadenosine supplier, inhibitors, inhibits, adenosine, deaminase, Deaminases, 4488, Tocris Bioscience
2 Citations for 1-Deazaadenosine
Citations are publications that use Tocris products. Selected citations for 1-Deazaadenosine include:
Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Anticancer Res 3 e00121 PMID: 26038697
Alexey et al (2022) Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases. EMBO J 41 e111608 PMID: 35833542
Do you know of a great paper that uses 1-Deazaadenosine from Tocris? Please let us know.
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Literature in this Area
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