Inhibitor of adenosine deaminase (Ki = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 266.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.76 mL||18.78 mL||37.56 mL|
|5 mM||0.75 mL||3.76 mL||7.51 mL|
|10 mM||0.38 mL||1.88 mL||3.76 mL|
|50 mM||0.08 mL||0.38 mL||0.75 mL|
References are publications that support the biological activity of the product.
Cristalli et al (1993) Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. 28 253
Cristalli et al (1987) Improved synthesis and antitumor activity of 1-deazaadenosine. J.Med.Chem. 30 1686 PMID: 3625714
If you know of a relevant reference for 1-Deazaadenosine, please let us know.
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Keywords: 1-Deazaadenosine, 1-Deazaadenosine supplier, inhibitors, inhibits, adenosine, deaminase, Deaminases, 4488, Tocris Bioscience
1 Citation for 1-Deazaadenosine
Citations are publications that use Tocris products. Selected citations for 1-Deazaadenosine include:
Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Anticancer Res 3 e00121 PMID: 26038697
Do you know of a great paper that uses 1-Deazaadenosine from Tocris? Please let us know.
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