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Description: Adenosine deaminase inhibitor
Chemical Name: 3-β-D-Ribofuranosyl-3H-imidazo[4,5-b]pyridin-7-amine
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for 1-Deazaadenosine

1-Deazaadenosine is an inhibitor of adenosine deaminase (Ki = 0.66 μM). Demonstrates antitumor activity in a range of leukemia cell lines.

Technical Data for 1-Deazaadenosine

M. Wt 266.25
Formula C11H14N4O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 14432-09-8
PubChem ID 159738
Smiles NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1-Deazaadenosine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.66 25

Preparing Stock Solutions for 1-Deazaadenosine

The following data is based on the product molecular weight 266.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 15.02 mL 75.12 mL 150.23 mL
1.25 mM 3 mL 15.02 mL 30.05 mL
2.5 mM 1.5 mL 7.51 mL 15.02 mL
12.5 mM 0.3 mL 1.5 mL 3 mL

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Product Datasheets for 1-Deazaadenosine

References for 1-Deazaadenosine

References are publications that support the biological activity of the product.

Cristalli et al (1993) Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. 28 253

Cristalli et al (1987) Improved synthesis and antitumor activity of 1-deazaadenosine. J.Med.Chem. 30 1686 PMID: 3625714

If you know of a relevant reference for 1-Deazaadenosine, please let us know.

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Keywords: 1-Deazaadenosine, 1-Deazaadenosine supplier, inhibitors, inhibits, adenosine, deaminase, Deaminases, 4488, Tocris Bioscience

2 Citations for 1-Deazaadenosine

Citations are publications that use Tocris products. Selected citations for 1-Deazaadenosine include:

Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Anticancer Res 3 e00121 PMID: 26038697

Alexey et al (2022) Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2'-O-ribose methyltransferases. EMBO J 41 e111608 PMID: 35833542

Do you know of a great paper that uses 1-Deazaadenosine from Tocris? Please let us know.

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